Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

gemfibrozil

Synonyms

Lopid

Definitions

A fibric acid derivative with hypolipidemic effects. Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III results in subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C). Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29071" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29071" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000715911

altLabel

Lopid

CAS Registry

25812-30-0

cui

C0017245

C0700003

DATE FIRST PUBLISHED

2011-11-02

Date last modified

2011-11-02

definition

A fibric acid derivative with hypolipidemic effects. Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III results in subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C). Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29071" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29071" NCI Thesaurus)

LT

TRD

NCI ID

C29071

notation

CDR0000715911

ORIG STY

Drug/agent

prefLabel

gemfibrozil

tui

T109

T121

Delete Subject Author Type Created
No notes to display
Create mapping

Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/RXNORM/202999 RXNORM CUI
http://purl.bioontology.org/ontology/NDFRT/N0000007039 NDFRT CUI
http://purl.bioontology.org/ontology/VANDF/4018639 VANDF CUI
http://purl.bioontology.org/ontology/SNMI/C-80660 SNMI CUI
http://purl.bioontology.org/ontology/LNC/LP15168-5 LOINC CUI
http://purl.bioontology.org/ontology/ATC/C10AB04 ATC CUI
http://purl.bioontology.org/ontology/LNC/MTHU002557 LOINC CUI
http://purl.bioontology.org/ontology/SNOMEDCT/35282000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/RCD/bx6.. RCD CUI
http://purl.bioontology.org/ontology/CSP/5001-0016 CRISP CUI
http://purl.bioontology.org/ontology/RXNORM/4719 RXNORM CUI
http://purl.bioontology.org/ontology/NDDF/002050 NDDF CUI
http://purl.bioontology.org/ontology/MSHFRE/D015248 MSHFRE CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146952 NDFRT CUI
http://purl.bioontology.org/ontology/SCTSPA/387189002 SCTSPA CUI
http://purl.bioontology.org/ontology/SCTSPA/35282000 SCTSPA CUI
http://purl.bioontology.org/ontology/MESH/D015248 MESH CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387189002 SNOMEDCT CUI
http://purl.bioontology.org/ontology/CSP/5001-0016 CRISP CUI
http://purl.bioontology.org/ontology/RCD/x02hs RCD CUI
http://purl.bioontology.org/ontology/MESH/D015248 MESH CUI
http://sbmi.uth.tmc.edu/ontology/ochv#C0017245 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.657.654.305.750 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 NIFSTD LOOM
http://purl.obolibrary.org/obo/OMIT_0016038 OMIT LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02186 MIO LOOM
http://www.ustb.edu.cn/thesauri/tocr/v1/data#C571353432175145020 ACVD_ONTOLOGY LOOM
http://stirdf.jst.go.jp/id/200907081927122227 IOBC LOOM
http://www.drugbank.ca/drugs/DB01241 FTC LOOM
http://purl.bioontology.org/ontology/VANDF/4018639 VANDF LOOM
http://purl.bioontology.org/ontology/SNMI/C-80660 SNMI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.355.726.305.750 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP15168-5 LOINC LOOM
http://purl.bioontology.org/ontology/ATC/C10AB04 ATC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU002557 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015248 RH-MESH LOOM
http://www.semanticweb.org/ontologies/STO.owl#e237d4_9d0d_4d99_b7ca_b43bbf5b5925 STO-DRAFT LOOM
http://www.semanticweb.org/ontologies/STO.owl#e237d4_9d0d_4d99_b7ca_b43bbf5b5925 CVAO LOOM
http://purl.jp/bio/4/id/200906031161703582 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D10.251.400.895.593.350 RH-MESH LOOM
http://purl.bioontology.org/ontology/CSP/5001-0016 CRISP LOOM
http://purl.bioontology.org/ontology/RXNORM/4719 RXNORM LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29071 NCIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.081.114.968.500.750 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Gemfibrozil GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.081.944.509.350 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146952 NDFRT LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016329 PMAPP-PMO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#5401 OCHV LOOM
http://purl.obolibrary.org/obo/MESH_D015248 BERO LOOM
http://purl.obolibrary.org/obo/NCIT_C29071 BERO LOOM
http://purl.bioontology.org/ontology/MESH/D015248 MESH LOOM
https://go.drugbank.com/drugs/DB01241 MDM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387189002 SNOMEDCT LOOM