Preferred Name |
gemfibrozil |
|
Synonyms |
Lopid |
|
Definitions |
A fibric acid derivative with hypolipidemic effects. Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III results in subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C). Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29071" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29071" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000715911 |
|
altLabel |
Lopid |
|
CAS Registry |
25812-30-0 |
|
cui |
C0017245 C0700003 |
|
DATE FIRST PUBLISHED |
2011-11-02 |
|
Date last modified |
2011-11-02 |
|
definition |
A fibric acid derivative with hypolipidemic effects. Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III results in subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C). Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29071" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29071" NCI Thesaurus) |
|
LT |
TRD |
|
NCI ID |
C29071 |
|
notation |
CDR0000715911 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
gemfibrozil |
|
tui |
T109 T121 |