loading...| Preferred Name |
varenicline |
|
| Synonyms |
7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine (2R,3R)-2,3-dihydroxybutqanedioate |
|
| Definitions |
A partial agonist of the nicotinic acetylcholine receptor (nAChR) subtype alpha4beta2. Nicotine stimulation of central alpha4beta2 nAChRs located at presynaptic terminals in the nucleus accumbens causes the release of the neurotransmitter dopamine, which may be associated with the experience of pleasure; nicotine addiction constitutes a physiologic dependence related to this dopaminergic reward system. As an AChR partial agonist, varenicline attenuates the craving and withdrawal symptoms that occur with abstinence from nicotine but is not habit-forming itself. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C73609" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C73609" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000584706 |
|
| altLabel |
7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine (2R,3R)-2,3-dihydroxybutqanedioate CP-526555 6,10-methano-6H-pyrazino[2,3-h][3]benzazeprine, 7,8,9,10-tetrahydro, (2R,3R)-2,3-dihydroxybutanedioate (1:1) Champix Chantix |
|
| cui |
C1712042 C2919038 C1569608 C1956439 |
|
| DATE FIRST PUBLISHED |
2008-01-11 |
|
| Date last modified |
2008-06-25 |
|
| definition |
A partial agonist of the nicotinic acetylcholine receptor (nAChR) subtype alpha4beta2. Nicotine stimulation of central alpha4beta2 nAChRs located at presynaptic terminals in the nucleus accumbens causes the release of the neurotransmitter dopamine, which may be associated with the experience of pleasure; nicotine addiction constitutes a physiologic dependence related to this dopaminergic reward system. As an AChR partial agonist, varenicline attenuates the craving and withdrawal symptoms that occur with abstinence from nicotine but is not habit-forming itself. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C73609" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C73609" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C73609 |
|
| notation |
CDR0000584706 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
varenicline |
|
| tui |
T109 T121 |