Preferred Name |
liposome-encapsulated doxorubicin citrate |
|
Synonyms |
Myocet |
|
Definitions |
A formulation of the citrate salt of the antineoplastic anthracycline antibiotic doxorubicin, encapsulated within liposomes, with antitumor activity. Doxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and RNA synthesis. This agent also interacts with cell membrane lipids causing lipid peroxidation. Liposomal delivery of doxorubicin improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects while lowering the toxicity profile. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61317" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61317" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000481301 |
|
altLabel |
Myocet |
|
cui |
C1512062 C1831805 |
|
DATE FIRST PUBLISHED |
2006-04-20 |
|
Date last modified |
2007-01-29 |
|
definition |
A formulation of the citrate salt of the antineoplastic anthracycline antibiotic doxorubicin, encapsulated within liposomes, with antitumor activity. Doxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and RNA synthesis. This agent also interacts with cell membrane lipids causing lipid peroxidation. Liposomal delivery of doxorubicin improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects while lowering the toxicity profile. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61317" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61317" NCI Thesaurus) |
|
LT |
TRD |
|
NCI ID |
C61317 |
|
notation |
CDR0000481301 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
liposome-encapsulated doxorubicin citrate |
|
tui |
T109 T195 |
Delete | Mapping To | Ontology | Source |
---|---|---|---|
http://purl.bioontology.org/ontology/MESH/D004317 | MESH | CUI | |
http://purl.obolibrary.org/obo/NCIT_C61317 | BERO | LOOM | |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61317 | NCIT | LOOM |