Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

liposome-encapsulated doxorubicin citrate

Synonyms

Myocet

Definitions

A formulation of the citrate salt of the antineoplastic anthracycline antibiotic doxorubicin, encapsulated within liposomes, with antitumor activity. Doxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and RNA synthesis. This agent also interacts with cell membrane lipids causing lipid peroxidation. Liposomal delivery of doxorubicin improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects while lowering the toxicity profile. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61317" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61317" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000481301

altLabel

Myocet

cui

C1512062

C1831805

DATE FIRST PUBLISHED

2006-04-20

Date last modified

2007-01-29

definition

A formulation of the citrate salt of the antineoplastic anthracycline antibiotic doxorubicin, encapsulated within liposomes, with antitumor activity. Doxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and RNA synthesis. This agent also interacts with cell membrane lipids causing lipid peroxidation. Liposomal delivery of doxorubicin improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects while lowering the toxicity profile. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61317" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61317" NCI Thesaurus)

LT

TRD

NCI ID

C61317

notation

CDR0000481301

ORIG STY

Drug/agent

prefLabel

liposome-encapsulated doxorubicin citrate

tui

T109

T195

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