Preferred Name |
resveratrol |
|
Synonyms |
(E)-5-[2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol |
|
Definitions |
A phytoalexin derived from grapes and other food products with antioxidant and potential chemopreventive activities. Resveratrol induces phase II drug-metabolizing enzymes (anti-initiation activity); mediates anti-inflammatory effects and inhibits cyclooxygenase and hydroperoxidase functions (anti-promotion activity); and induces promyelocytic leukemia cell differentiation (anti-progression activity), thereby exhibiting activities in three major steps of carcinogenesis. This agent may inhibit TNF-induced activation of NF-kappaB in a dose- and time-dependent manner. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1215" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1215" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000405819 |
|
altLabel |
(E)-5-[2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol 3,4',5-stilbenetriol |
|
cui |
C0073096 |
|
DATE FIRST PUBLISHED |
2004-11-22 |
|
Date last modified |
2008-10-13 |
|
definition |
A phytoalexin derived from grapes and other food products with antioxidant and potential chemopreventive activities. Resveratrol induces phase II drug-metabolizing enzymes (anti-initiation activity); mediates anti-inflammatory effects and inhibits cyclooxygenase and hydroperoxidase functions (anti-promotion activity); and induces promyelocytic leukemia cell differentiation (anti-progression activity), thereby exhibiting activities in three major steps of carcinogenesis. This agent may inhibit TNF-induced activation of NF-kappaB in a dose- and time-dependent manner. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1215" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1215" NCI Thesaurus) |
|
NCI ID |
C1215 |
|
notation |
CDR0000405819 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
resveratrol |
|
tui |
T109 T121 |