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Last uploaded: January 31, 2024
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Preferred Name

valproic acid
Synonyms

Alti-Valproic
Definitions

A synthetic derivative of propylpentanoic acid with antiepileptic properties and potential antineoplastic and antiangiogenesis activities. In epilepsy, valproic acid appears to act by increasing the concentration of gamma-aminobutyric acid (GABA) in the brain. This agent's antitumor and antiangiogenesis activities may be related to the inhibition of histone deacetylases and nitric oxide synthase, which results in the inhibition of nitric oxide synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29536" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29536" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000350047
altLabel

Alti-Valproic

Ergenyl

Novo-Valproic

Depacon

Valproate

Stavzor

2-Propylvaleric Acid

VA

2-Propylpentanoic Acid

Depakene

Di-n-propylacetic Acid

Valproate Sodium
CAS Registry

99-66-1
Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000353333
cui

C0037567

C1328122

C0700659

C0080356

C1328121

C0700661

C0719750

C0042291

C2356549
DATE FIRST PUBLISHED

2003-12-23
Date last modified

2016-01-14
definition

A synthetic derivative of propylpentanoic acid with antiepileptic properties and potential antineoplastic and antiangiogenesis activities. In epilepsy, valproic acid appears to act by increasing the concentration of gamma-aminobutyric acid (GABA) in the brain. This agent's antitumor and antiangiogenesis activities may be related to the inhibition of histone deacetylases and nitric oxide synthase, which results in the inhibition of nitric oxide synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29536" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29536" NCI Thesaurus)
LT

TRD
NCI ID

C29536
notation

CDR0000350047
NSC Code

93819
ORIG STY

Drug/agent
prefLabel

valproic acid
tui

T109

T121
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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/VANDF/4018724 VANDF CUI
http://purl.bioontology.org/ontology/MESH/D014635 MESH CUI
http://purl.bioontology.org/ontology/RXNORM/40254 RXNORM CUI
http://purl.bioontology.org/ontology/MESH/D014635 MESH CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387080000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MESH/D014635 MESH CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387481005 SNOMEDCT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000178986 NDFRT CUI
http://purl.bioontology.org/ontology/SNMI/C-61131 SNMI CUI
http://purl.bioontology.org/ontology/NDDF/001623 NDDF CUI
http://purl.bioontology.org/ontology/RCD/dnb.. RCD CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147029 NDFRT CUI
http://purl.bioontology.org/ontology/MSHFRE/D014635 MSHFRE CUI
http://purl.bioontology.org/ontology/SCTSPA/387481005 SCTSPA CUI
http://purl.bioontology.org/ontology/RXNORM/9919 RXNORM CUI
http://purl.bioontology.org/ontology/RCD/x00Bp RCD CUI
http://purl.bioontology.org/ontology/MESH/D014635 MESH CUI
http://purl.bioontology.org/ontology/SNMI/C-61130 SNMI CUI
http://purl.bioontology.org/ontology/SCTSPA/264325000 SCTSPA CUI
http://purl.bioontology.org/ontology/RCD/XC0RS RCD CUI
http://purl.bioontology.org/ontology/SNOMEDCT/264325000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/LNC/LP16305-2 LOINC CUI
http://purl.bioontology.org/ontology/LNC/MTHU005126 LOINC CUI
http://purl.bioontology.org/ontology/CSP/0562-9957 CRISP CUI
http://purl.bioontology.org/ontology/MSHFRE/D014635 MSHFRE CUI
http://purl.bioontology.org/ontology/ATC/N03AG01 ATC CUI
http://purl.bioontology.org/ontology/MESH/D014635 MESH CUI
http://purl.bioontology.org/ontology/SCTSPA/13965000 SCTSPA CUI
http://purl.bioontology.org/ontology/VANDF/4018723 VANDF CUI
http://purl.bioontology.org/ontology/SCTSPA/387080000 SCTSPA CUI
http://purl.bioontology.org/ontology/SNMI/C-61132 SNMI CUI
http://purl.bioontology.org/ontology/RXNORM/11118 RXNORM CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147028 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006250 NDFRT CUI
http://purl.bioontology.org/ontology/VANDF/4022507 VANDF CUI
http://purl.bioontology.org/ontology/NDDF/001622 NDDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/13965000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MSHFRE/D014635 MSHFRE CUI
http://purl.bioontology.org/ontology/RCD/dnh.. RCD CUI
http://purl.bioontology.org/ontology/NDFRT/N0000020512 NDFRT CUI
http://purl.obolibrary.org/obo/CHEBI_39867 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 CHEBI LOOM
http://www.case.edu/EpilepsyOntology.owl#ValproicAcid EPSO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387080000 SNOMEDCT LOOM
http://www.case.edu/EpSO.owl#ValproicAcid MEPO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0042291 OCHV LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 OBI LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 COVID-19 LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 CIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 NIFSTD LOOM
http://purl.obolibrary.org/obo/OMIT_0015469 OMIT LOOM
http://purl.bioontology.org/ontology/ATC/N03AG01 ATC LOOM
http://purl.bioontology.org/ontology/MESH/D014635 MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4018723 VANDF LOOM
http://stirdf.jst.go.jp/id/200907057055574563 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014635 RH-MESH LOOM
http://doe-generated-ontology.com/OntoAD#C0042291 ONTOAD LOOM
http://purl.jp/bio/4/id/200906053586959002 IOBC LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Valproic_Acid APAONTO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12885 OCHV LOOM
http://purl.bioontology.org/ontology/SNMI/C-61132 SNMI LOOM
http://purl.bioontology.org/ontology/RXNORM/11118 RXNORM LOOM
http://purl.obolibrary.org/obo/NCIT_C29536 BERO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147028 NDFRT LOOM
http://www.semanticweb.org/cjf/ontologies/2022/8/NeuralReprogrammingOntology(NRO)#Valproic_acid NRO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.081.944.509.900 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016455 PMAPP-PMO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29536 NCIT LOOM
https://go.drugbank.com/drugs/DB00313 MDM LOOM
http://purl.bioontology.org/ontology/NDDF/001622 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D10.251.400.895.593.900 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/dnh.. RCD LOOM
http://www.drugbank.ca/drugs/DB00313 FTC LOOM
http://www.semanticweb.org/ftuha/ontologies/2021/5/FRMO-01untitled-ontology-175/Valproic_Acid FRMO LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Valproic_acid STMSO LOOM
http://purl.obolibrary.org/obo/MESH_D014635 BERO LOOM