Preferred Name |
lamotrigine |
|
Synonyms |
Lamictal |
|
Definitions |
A synthetic phenyltriazine with antiepileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid, an inhibitory neurotransmitter, which may result in a reduction of pain-related transmission of signals along nerve fibers. This agent may also inhibit voltage-gated sodium channels, suppress glutamate release, and inhibit serotonin reuptake. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C38703" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C38703" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000328241 |
|
altLabel |
Lamictal |
|
cui |
C0678180 C0064636 |
|
DATE FIRST PUBLISHED |
2003-08-24 |
|
Date last modified |
2006-08-28 |
|
definition |
A synthetic phenyltriazine with antiepileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid, an inhibitory neurotransmitter, which may result in a reduction of pain-related transmission of signals along nerve fibers. This agent may also inhibit voltage-gated sodium channels, suppress glutamate release, and inhibit serotonin reuptake. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C38703" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C38703" NCI Thesaurus) |
|
LT |
TRD |
|
NCI ID |
C38703 |
|
notation |
CDR0000328241 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
lamotrigine |
|
tui |
T109 T121 |