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A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C769" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C769" NCI Thesaurus)
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Pred-Clysma Predni-Helvacort Dontisolon D (11beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione Panafcortelone Prenilone Predni-Coelin Decortin H Deltasolone PRDL 1,2-dehydrohydrocortisone metacortandralone Linola-H-Fett N Deltidrosol Decaprednil Delta- Cortef Lenisolone Delta-Phoricol Frisolona Gupisone Cortisolone Linola-H N Kuhlprednon Capsoid Fisopred Meti-derm Aprednislon Dacortin H Adnisolone Dhasolone Delta-Diona Klismacort Hostacortin H delta(1)hydrocortisone Hydeltrasol Cortalone delta1-dehydro-hydrocortisone deltahydrocortisone Prelone Lepi-Cortinolo Deltacortril Estilsona Predeltilone Prednicortelone Opredsone Delta-Cortef Meticortelone Precortisyl Di-Adreson-F Longiprednil Hydeltra
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definition |
A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C769" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C769" NCI Thesaurus)
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