loading...| Preferred Name |
gonadotrophin releasing hormone analogue |
|
| Synonyms |
gonadorelin |
|
| Definitions |
A synthetic analog of the endogenous hormone gonadotropin-releasing hormone (GnRH), with potential antineoplastic activity. Upon administration, GnRH analog mimics endogenous GnRH and strongly binds to and activates pituitary GnRH receptors, which stimulates the synthesis and secretion of the gonadotropic hormones, follicle stimulating hormone (FSH) and luteinizing hormone (LH). Continuous, prolonged activation by the GnRH analog results in pituitary GnRH receptor desensitization and receptor downregulation. This causes inhibition of pituitary gonadotropin secretion of LH and FSH. In males, the inhibition of LH secretion prevents the production and release of testosterone from Leydig cells in the testes and causes a significant decline in testosterone production that is near the levels seen after castration. This may inhibit androgen receptor-positive tumor progression. In females, this results in a decrease in estradiol production. GnRH, also called luteinizing hormone-releasing hormone (LH-RH), is normally synthesized in and secreted by the hypothalamus. Synthetic analogs of GnRH have a stronger receptor binding affinity than the endogenous form. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1910" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1910" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042628 |
|
| altLabel |
gonadorelin LHRH analogue gonadoliberin luliberin Hoe- 471 LH-RH analogs AY-24031 LH/FSH-RF analogue GN-RH analogue LH-RF analogue luteinizing hormone-releasing hormone agonist D-His-6-Pro-8-NEt-LHRH gonadorelinum GnRH analogue luteinising hormone-releasing factor analogue LH/FSH-RH analogue follicle stimulating hormone-releasing factor |
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| Component of | ||
| cui |
C5441718 C0023610 C1518041 C1521755 |
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| Date last modified |
2014-05-29 |
|
| definition |
A synthetic analog of the endogenous hormone gonadotropin-releasing hormone (GnRH), with potential antineoplastic activity. Upon administration, GnRH analog mimics endogenous GnRH and strongly binds to and activates pituitary GnRH receptors, which stimulates the synthesis and secretion of the gonadotropic hormones, follicle stimulating hormone (FSH) and luteinizing hormone (LH). Continuous, prolonged activation by the GnRH analog results in pituitary GnRH receptor desensitization and receptor downregulation. This causes inhibition of pituitary gonadotropin secretion of LH and FSH. In males, the inhibition of LH secretion prevents the production and release of testosterone from Leydig cells in the testes and causes a significant decline in testosterone production that is near the levels seen after castration. This may inhibit androgen receptor-positive tumor progression. In females, this results in a decrease in estradiol production. GnRH, also called luteinizing hormone-releasing hormone (LH-RH), is normally synthesized in and secreted by the hypothalamus. Synthetic analogs of GnRH have a stronger receptor binding affinity than the endogenous form. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1910" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1910" NCI Thesaurus) |
|
| Legacy PDQ ID |
635 |
|
| NCI ID |
C1910 |
|
| notation |
CDR0000042628 |
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| ORIG STY |
Drug/agent |
|
| prefLabel |
gonadotrophin releasing hormone analogue |
|
| tui |
T125 T116 T121 |