loading...| Preferred Name |
letrozole |
|
| Synonyms |
4,4'-(1H-1,2,4triazol-1-ylmethylene)dibenzonitrile |
|
| Definitions |
A nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1527" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1527" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042086 |
|
| altLabel |
4,4'-(1H-1,2,4triazol-1-ylmethylene)dibenzonitrile LTZ Femara CGS 20267 |
|
| CAS Registry |
112809-51-5 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000410777 http://purl.bioontology.org/ontology/PDQ/CDR0000415928 http://purl.bioontology.org/ontology/PDQ/CDR0000042379 http://purl.bioontology.org/ontology/PDQ/CDR0000305872 |
|
| cui |
C0701347 C0701348 C0246421 |
|
| Date last modified |
2009-12-15 |
|
| definition |
A nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1527" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1527" NCI Thesaurus) |
|
| Legacy PDQ ID |
5321 |
|
| LT |
TRD |
|
| NCI ID |
C1527 |
|
| notation |
CDR0000042086 |
|
| NSC Code |
719345 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
letrozole |
|
| tui |
T109 T121 |