loading...| Preferred Name |
therapeutic epinephrine |
|
| Synonyms |
epi |
|
| Definitions |
The synthetic form of the naturally occurring sympathomimetic amine with vasoconstricting, intraocular pressure-reducing, and bronchodilating activities. By stimulating vascular alpha-adrenergic receptors, epinephrine causes vasoconstriction, thereby increasing vascular resistance and blood pressure. When administered in the conjunctiva, this agent binds to alpha-adrenergic receptors in the iris sphincter muscle, resulting in vasoconstriction, a decrease in the production of aqueous humor, and a lowering of intraocular pressure. Through its beta1 receptor-stimulating actions, epinephrine increases the force and rate of myocardial contraction and relaxes bronchial smooth muscle, resulting in bronchodilation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C473" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C473" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000041857 |
|
| altLabel |
epi epinephrine adrenaline |
|
| cui |
C0014563 |
|
| Date last modified |
2008-10-16 |
|
| definition |
The synthetic form of the naturally occurring sympathomimetic amine with vasoconstricting, intraocular pressure-reducing, and bronchodilating activities. By stimulating vascular alpha-adrenergic receptors, epinephrine causes vasoconstriction, thereby increasing vascular resistance and blood pressure. When administered in the conjunctiva, this agent binds to alpha-adrenergic receptors in the iris sphincter muscle, resulting in vasoconstriction, a decrease in the production of aqueous humor, and a lowering of intraocular pressure. Through its beta1 receptor-stimulating actions, epinephrine increases the force and rate of myocardial contraction and relaxes bronchial smooth muscle, resulting in bronchodilation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C473" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C473" NCI Thesaurus) |
|
| Legacy PDQ ID |
5069 |
|
| NCI ID |
C473 |
|
| notation |
CDR0000041857 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
therapeutic epinephrine |
|
| tui |
T125 T109 T121 |