Physician Data Query

Last uploaded: January 31, 2024

Details
Visualization
Notes ( 0 )
Class Mappings ( )

Preferred Name	methotrexate
Synonyms	Emtexate
Definitions	An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C642" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C642" NCI Thesaurus)
ID	http://purl.bioontology.org/ontology/PDQ/CDR0000041719
altLabel	Emtexate Ledertrexate Rheumatrex Metex Tremetex Lantarel Metotrexato Brimexate Novatrex amethopterin 4-amino-4-deoxy-10-methylpteroyl-L-glutamic acid Trexall MTX Methoblastin Emthexate Lumexon methotrexate methylaminopterin Trixilem 4-amino-10-methylfolic acid methylaminopterin Maxtrex Metrotex CL-14377 Emthexat Farmitrexat Fauldexato WR-19039 Texate Trexeron Methotrexatum N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid alpha-methopterin Medsatrexate
CAS Registry	59-05-2
Component of	http://purl.bioontology.org/ontology/PDQ/CDR0000039705 http://purl.bioontology.org/ontology/PDQ/CDR0000043002 http://purl.bioontology.org/ontology/PDQ/CDR0000040948 http://purl.bioontology.org/ontology/PDQ/CDR0000040601 http://purl.bioontology.org/ontology/PDQ/CDR0000437891 http://purl.bioontology.org/ontology/PDQ/CDR0000043217 http://purl.bioontology.org/ontology/PDQ/CDR0000039428 http://purl.bioontology.org/ontology/PDQ/CDR0000040493 http://purl.bioontology.org/ontology/PDQ/CDR0000041434 http://purl.bioontology.org/ontology/PDQ/CDR0000041034 http://purl.bioontology.org/ontology/PDQ/CDR0000042946 http://purl.bioontology.org/ontology/PDQ/CDR0000040656 http://purl.bioontology.org/ontology/PDQ/CDR0000039325 http://purl.bioontology.org/ontology/PDQ/CDR0000041080 http://purl.bioontology.org/ontology/PDQ/CDR0000041784 http://purl.bioontology.org/ontology/PDQ/CDR0000037782 http://purl.bioontology.org/ontology/PDQ/CDR0000039403 http://purl.bioontology.org/ontology/PDQ/CDR0000041314 http://purl.bioontology.org/ontology/PDQ/CDR0000039351 http://purl.bioontology.org/ontology/PDQ/CDR0000299000 http://purl.bioontology.org/ontology/PDQ/CDR0000038858 http://purl.bioontology.org/ontology/PDQ/CDR0000041813 http://purl.bioontology.org/ontology/PDQ/CDR0000041980 http://purl.bioontology.org/ontology/PDQ/CDR0000040905 http://purl.bioontology.org/ontology/PDQ/CDR0000038399 http://purl.bioontology.org/ontology/PDQ/CDR0000038311 http://purl.bioontology.org/ontology/PDQ/CDR0000041180 http://purl.bioontology.org/ontology/PDQ/CDR0000040284 http://purl.bioontology.org/ontology/PDQ/CDR0000038436 http://purl.bioontology.org/ontology/PDQ/CDR0000040507 http://purl.bioontology.org/ontology/PDQ/CDR0000039414 http://purl.bioontology.org/ontology/PDQ/CDR0000043064 http://purl.bioontology.org/ontology/PDQ/CDR0000038582 http://purl.bioontology.org/ontology/PDQ/CDR0000040919 http://purl.bioontology.org/ontology/PDQ/CDR0000039473 http://purl.bioontology.org/ontology/PDQ/CDR0000038014 http://purl.bioontology.org/ontology/PDQ/CDR0000040421 http://purl.bioontology.org/ontology/PDQ/CDR0000037834 http://purl.bioontology.org/ontology/PDQ/CDR0000041639 http://purl.bioontology.org/ontology/PDQ/CDR0000042242 http://purl.bioontology.org/ontology/PDQ/CDR0000040401 http://purl.bioontology.org/ontology/PDQ/CDR0000037927 http://purl.bioontology.org/ontology/PDQ/CDR0000041597 http://purl.bioontology.org/ontology/PDQ/CDR0000041691 http://purl.bioontology.org/ontology/PDQ/CDR0000039468 http://purl.bioontology.org/ontology/PDQ/CDR0000393427 http://purl.bioontology.org/ontology/PDQ/CDR0000040282 http://purl.bioontology.org/ontology/PDQ/CDR0000042091 http://purl.bioontology.org/ontology/PDQ/CDR0000041001 http://purl.bioontology.org/ontology/PDQ/CDR0000041238 http://purl.bioontology.org/ontology/PDQ/CDR0000041940 http://purl.bioontology.org/ontology/PDQ/CDR0000041173 http://purl.bioontology.org/ontology/PDQ/CDR0000041444 http://purl.bioontology.org/ontology/PDQ/CDR0000038700 http://purl.bioontology.org/ontology/PDQ/CDR0000039668 http://purl.bioontology.org/ontology/PDQ/CDR0000039024 http://purl.bioontology.org/ontology/PDQ/CDR0000039445 http://purl.bioontology.org/ontology/PDQ/CDR0000038132 http://purl.bioontology.org/ontology/PDQ/CDR0000344418 http://purl.bioontology.org/ontology/PDQ/CDR0000039609 http://purl.bioontology.org/ontology/PDQ/CDR0000041471 http://purl.bioontology.org/ontology/PDQ/CDR0000043306 http://purl.bioontology.org/ontology/PDQ/CDR0000040943 http://purl.bioontology.org/ontology/PDQ/CDR0000041672 http://purl.bioontology.org/ontology/PDQ/CDR0000039671 http://purl.bioontology.org/ontology/PDQ/CDR0000038255 http://purl.bioontology.org/ontology/PDQ/CDR0000038875 http://purl.bioontology.org/ontology/PDQ/CDR0000041006 http://purl.bioontology.org/ontology/PDQ/CDR0000041831 http://purl.bioontology.org/ontology/PDQ/CDR0000299571 http://purl.bioontology.org/ontology/PDQ/CDR0000039699 http://purl.bioontology.org/ontology/PDQ/CDR0000038862 http://purl.bioontology.org/ontology/PDQ/CDR0000039772 http://purl.bioontology.org/ontology/PDQ/CDR0000038360 http://purl.bioontology.org/ontology/PDQ/CDR0000043392 http://purl.bioontology.org/ontology/PDQ/CDR0000043052 http://purl.bioontology.org/ontology/PDQ/CDR0000416130 http://purl.bioontology.org/ontology/PDQ/CDR0000270386 http://purl.bioontology.org/ontology/PDQ/CDR0000039098 http://purl.bioontology.org/ontology/PDQ/CDR0000040966 http://purl.bioontology.org/ontology/PDQ/CDR0000040572 http://purl.bioontology.org/ontology/PDQ/CDR0000445423 http://purl.bioontology.org/ontology/PDQ/CDR0000041492 http://purl.bioontology.org/ontology/PDQ/CDR0000041977 http://purl.bioontology.org/ontology/PDQ/CDR0000271395 http://purl.bioontology.org/ontology/PDQ/CDR0000041062 http://purl.bioontology.org/ontology/PDQ/CDR0000038286 http://purl.bioontology.org/ontology/PDQ/CDR0000038310 http://purl.bioontology.org/ontology/PDQ/CDR0000038878 http://purl.bioontology.org/ontology/PDQ/CDR0000393425 http://purl.bioontology.org/ontology/PDQ/CDR0000043395 http://purl.bioontology.org/ontology/PDQ/CDR0000040898 http://purl.bioontology.org/ontology/PDQ/CDR0000039380 http://purl.bioontology.org/ontology/PDQ/CDR0000041068 http://purl.bioontology.org/ontology/PDQ/CDR0000043397 http://purl.bioontology.org/ontology/PDQ/CDR0000039420 http://purl.bioontology.org/ontology/PDQ/CDR0000040988 http://purl.bioontology.org/ontology/PDQ/CDR0000040787 http://purl.bioontology.org/ontology/PDQ/CDR0000040161 http://purl.bioontology.org/ontology/PDQ/CDR0000038879 http://purl.bioontology.org/ontology/PDQ/CDR0000038361 http://purl.bioontology.org/ontology/PDQ/CDR0000043323 http://purl.bioontology.org/ontology/PDQ/CDR0000350091 http://purl.bioontology.org/ontology/PDQ/CDR0000038877 http://purl.bioontology.org/ontology/PDQ/CDR0000041378 http://purl.bioontology.org/ontology/PDQ/CDR0000039341 http://purl.bioontology.org/ontology/PDQ/CDR0000041098 http://purl.bioontology.org/ontology/PDQ/CDR0000043399 http://purl.bioontology.org/ontology/PDQ/CDR0000043402 http://purl.bioontology.org/ontology/PDQ/CDR0000042940 http://purl.bioontology.org/ontology/PDQ/CDR0000038017 http://purl.bioontology.org/ontology/PDQ/CDR0000039426 http://purl.bioontology.org/ontology/PDQ/CDR0000039815 http://purl.bioontology.org/ontology/PDQ/CDR0000040216 http://purl.bioontology.org/ontology/PDQ/CDR0000041594 http://purl.bioontology.org/ontology/PDQ/CDR0000040889 http://purl.bioontology.org/ontology/PDQ/CDR0000041071 http://purl.bioontology.org/ontology/PDQ/CDR0000040418 http://purl.bioontology.org/ontology/PDQ/CDR0000041000 http://purl.bioontology.org/ontology/PDQ/CDR0000041065 http://purl.bioontology.org/ontology/PDQ/CDR0000038435 http://purl.bioontology.org/ontology/PDQ/CDR0000039791 http://purl.bioontology.org/ontology/PDQ/CDR0000040941 http://purl.bioontology.org/ontology/PDQ/CDR0000040260 http://purl.bioontology.org/ontology/PDQ/CDR0000039438 http://purl.bioontology.org/ontology/PDQ/CDR0000038292 http://purl.bioontology.org/ontology/PDQ/CDR0000039568 http://purl.bioontology.org/ontology/PDQ/CDR0000380452 http://purl.bioontology.org/ontology/PDQ/CDR0000043135 http://purl.bioontology.org/ontology/PDQ/CDR0000040896 http://purl.bioontology.org/ontology/PDQ/CDR0000041854 http://purl.bioontology.org/ontology/PDQ/CDR0000042173 http://purl.bioontology.org/ontology/PDQ/CDR0000038006 http://purl.bioontology.org/ontology/PDQ/CDR0000041609 http://purl.bioontology.org/ontology/PDQ/CDR0000041040 http://purl.bioontology.org/ontology/PDQ/CDR0000304318 http://purl.bioontology.org/ontology/PDQ/CDR0000041673 http://purl.bioontology.org/ontology/PDQ/CDR0000037786 http://purl.bioontology.org/ontology/PDQ/CDR0000042590 http://purl.bioontology.org/ontology/PDQ/CDR0000040413 http://purl.bioontology.org/ontology/PDQ/CDR0000039569 http://purl.bioontology.org/ontology/PDQ/CDR0000041312 http://purl.bioontology.org/ontology/PDQ/CDR0000039586 http://purl.bioontology.org/ontology/PDQ/CDR0000306480 http://purl.bioontology.org/ontology/PDQ/CDR0000041289 http://purl.bioontology.org/ontology/PDQ/CDR0000039044 http://purl.bioontology.org/ontology/PDQ/CDR0000040395 http://purl.bioontology.org/ontology/PDQ/CDR0000039317 http://purl.bioontology.org/ontology/PDQ/CDR0000298999 http://purl.bioontology.org/ontology/PDQ/CDR0000038693 http://purl.bioontology.org/ontology/PDQ/CDR0000258744 http://purl.bioontology.org/ontology/PDQ/CDR0000039397 http://purl.bioontology.org/ontology/PDQ/CDR0000038893 http://purl.bioontology.org/ontology/PDQ/CDR0000043401 http://purl.bioontology.org/ontology/PDQ/CDR0000040976 http://purl.bioontology.org/ontology/PDQ/CDR0000042171 http://purl.bioontology.org/ontology/PDQ/CDR0000041328 http://purl.bioontology.org/ontology/PDQ/CDR0000039516 http://purl.bioontology.org/ontology/PDQ/CDR0000043394 http://purl.bioontology.org/ontology/PDQ/CDR0000038883 http://purl.bioontology.org/ontology/PDQ/CDR0000038732 http://purl.bioontology.org/ontology/PDQ/CDR0000298997 http://purl.bioontology.org/ontology/PDQ/CDR0000043297 http://purl.bioontology.org/ontology/PDQ/CDR0000038396 http://purl.bioontology.org/ontology/PDQ/CDR0000038733 http://purl.bioontology.org/ontology/PDQ/CDR0000344423 http://purl.bioontology.org/ontology/PDQ/CDR0000039584 http://purl.bioontology.org/ontology/PDQ/CDR0000361547 http://purl.bioontology.org/ontology/PDQ/CDR0000301904 http://purl.bioontology.org/ontology/PDQ/CDR0000043308 http://purl.bioontology.org/ontology/PDQ/CDR0000040454 http://purl.bioontology.org/ontology/PDQ/CDR0000361812 http://purl.bioontology.org/ontology/PDQ/CDR0000038093 http://purl.bioontology.org/ontology/PDQ/CDR0000041996 http://purl.bioontology.org/ontology/PDQ/CDR0000038288 http://purl.bioontology.org/ontology/PDQ/CDR0000041733 http://purl.bioontology.org/ontology/PDQ/CDR0000042172 http://purl.bioontology.org/ontology/PDQ/CDR0000040124 http://purl.bioontology.org/ontology/PDQ/CDR0000041889 http://purl.bioontology.org/ontology/PDQ/CDR0000315771 http://purl.bioontology.org/ontology/PDQ/CDR0000041931 http://purl.bioontology.org/ontology/PDQ/CDR0000038308 http://purl.bioontology.org/ontology/PDQ/CDR0000040997 http://purl.bioontology.org/ontology/PDQ/CDR0000041493 http://purl.bioontology.org/ontology/PDQ/CDR0000040582 http://purl.bioontology.org/ontology/PDQ/CDR0000039025 http://purl.bioontology.org/ontology/PDQ/CDR0000040339 http://purl.bioontology.org/ontology/PDQ/CDR0000042362 http://purl.bioontology.org/ontology/PDQ/CDR0000039353 http://purl.bioontology.org/ontology/PDQ/CDR0000038766 http://purl.bioontology.org/ontology/PDQ/CDR0000038129 http://purl.bioontology.org/ontology/PDQ/CDR0000043330 http://purl.bioontology.org/ontology/PDQ/CDR0000039463 http://purl.bioontology.org/ontology/PDQ/CDR0000038640 http://purl.bioontology.org/ontology/PDQ/CDR0000041832 http://purl.bioontology.org/ontology/PDQ/CDR0000301638 http://purl.bioontology.org/ontology/PDQ/CDR0000405846 http://purl.bioontology.org/ontology/PDQ/CDR0000039687 http://purl.bioontology.org/ontology/PDQ/CDR0000041130 http://purl.bioontology.org/ontology/PDQ/CDR0000042644 http://purl.bioontology.org/ontology/PDQ/CDR0000393428 http://purl.bioontology.org/ontology/PDQ/CDR0000041497 http://purl.bioontology.org/ontology/PDQ/CDR0000039524 http://purl.bioontology.org/ontology/PDQ/CDR0000043681 http://purl.bioontology.org/ontology/PDQ/CDR0000042129 http://purl.bioontology.org/ontology/PDQ/CDR0000040082 http://purl.bioontology.org/ontology/PDQ/CDR0000038884 http://purl.bioontology.org/ontology/PDQ/CDR0000041879 http://purl.bioontology.org/ontology/PDQ/CDR0000041311 http://purl.bioontology.org/ontology/PDQ/CDR0000361813 http://purl.bioontology.org/ontology/PDQ/CDR0000039417 http://purl.bioontology.org/ontology/PDQ/CDR0000042396 http://purl.bioontology.org/ontology/PDQ/CDR0000043393 http://purl.bioontology.org/ontology/PDQ/CDR0000038287 http://purl.bioontology.org/ontology/PDQ/CDR0000040154 http://purl.bioontology.org/ontology/PDQ/CDR0000041855 http://purl.bioontology.org/ontology/PDQ/CDR0000040147 http://purl.bioontology.org/ontology/PDQ/CDR0000042556 http://purl.bioontology.org/ontology/PDQ/CDR0000042591 http://purl.bioontology.org/ontology/PDQ/CDR0000042018 http://purl.bioontology.org/ontology/PDQ/CDR0000041934 http://purl.bioontology.org/ontology/PDQ/CDR0000040984 http://purl.bioontology.org/ontology/PDQ/CDR0000038291 http://purl.bioontology.org/ontology/PDQ/CDR0000042294 http://purl.bioontology.org/ontology/PDQ/CDR0000042344 http://purl.bioontology.org/ontology/PDQ/CDR0000038374 http://purl.bioontology.org/ontology/PDQ/CDR0000040415 http://purl.bioontology.org/ontology/PDQ/CDR0000039535 http://purl.bioontology.org/ontology/PDQ/CDR0000043307 http://purl.bioontology.org/ontology/PDQ/CDR0000038876 http://purl.bioontology.org/ontology/PDQ/CDR0000039624 http://purl.bioontology.org/ontology/PDQ/CDR0000041956 http://purl.bioontology.org/ontology/PDQ/CDR0000043405 http://purl.bioontology.org/ontology/PDQ/CDR0000039622 http://purl.bioontology.org/ontology/PDQ/CDR0000040917 http://purl.bioontology.org/ontology/PDQ/CDR0000405845 http://purl.bioontology.org/ontology/PDQ/CDR0000043021 http://purl.bioontology.org/ontology/PDQ/CDR0000257375 http://purl.bioontology.org/ontology/PDQ/CDR0000041286 http://purl.bioontology.org/ontology/PDQ/CDR0000038443 http://purl.bioontology.org/ontology/PDQ/CDR0000039328 http://purl.bioontology.org/ontology/PDQ/CDR0000038013 http://purl.bioontology.org/ontology/PDQ/CDR0000042408 http://purl.bioontology.org/ontology/PDQ/CDR0000042519 http://purl.bioontology.org/ontology/PDQ/CDR0000380935 http://purl.bioontology.org/ontology/PDQ/CDR0000041490 http://purl.bioontology.org/ontology/PDQ/CDR0000041949 http://purl.bioontology.org/ontology/PDQ/CDR0000039647 http://purl.bioontology.org/ontology/PDQ/CDR0000040064 http://purl.bioontology.org/ontology/PDQ/CDR0000043298 http://purl.bioontology.org/ontology/PDQ/CDR0000043396 http://purl.bioontology.org/ontology/PDQ/CDR0000340940 http://purl.bioontology.org/ontology/PDQ/CDR0000041651 http://purl.bioontology.org/ontology/PDQ/CDR0000040465 http://purl.bioontology.org/ontology/PDQ/CDR0000039068 http://purl.bioontology.org/ontology/PDQ/CDR0000038577 http://purl.bioontology.org/ontology/PDQ/CDR0000042016 http://purl.bioontology.org/ontology/PDQ/CDR0000416131 http://purl.bioontology.org/ontology/PDQ/CDR0000040952 http://purl.bioontology.org/ontology/PDQ/CDR0000041033 http://purl.bioontology.org/ontology/PDQ/CDR0000038977 http://purl.bioontology.org/ontology/PDQ/CDR0000038840 http://purl.bioontology.org/ontology/PDQ/CDR0000038632 http://purl.bioontology.org/ontology/PDQ/CDR0000040353 http://purl.bioontology.org/ontology/PDQ/CDR0000038373 http://purl.bioontology.org/ontology/PDQ/CDR0000043125 http://purl.bioontology.org/ontology/PDQ/CDR0000043485 http://purl.bioontology.org/ontology/PDQ/CDR0000042424 http://purl.bioontology.org/ontology/PDQ/CDR0000038297 http://purl.bioontology.org/ontology/PDQ/CDR0000038851 http://purl.bioontology.org/ontology/PDQ/CDR0000043404 http://purl.bioontology.org/ontology/PDQ/CDR0000041310 http://purl.bioontology.org/ontology/PDQ/CDR0000039771 http://purl.bioontology.org/ontology/PDQ/CDR0000043400 http://purl.bioontology.org/ontology/PDQ/CDR0000041172 http://purl.bioontology.org/ontology/PDQ/CDR0000042123 http://purl.bioontology.org/ontology/PDQ/CDR0000041955 http://purl.bioontology.org/ontology/PDQ/CDR0000039635 http://purl.bioontology.org/ontology/PDQ/CDR0000445422 http://purl.bioontology.org/ontology/PDQ/CDR0000039043 http://purl.bioontology.org/ontology/PDQ/CDR0000041496 http://purl.bioontology.org/ontology/PDQ/CDR0000037906 http://purl.bioontology.org/ontology/PDQ/CDR0000039521 http://purl.bioontology.org/ontology/PDQ/CDR0000042001 http://purl.bioontology.org/ontology/PDQ/CDR0000040076 http://purl.bioontology.org/ontology/PDQ/CDR0000040935 http://purl.bioontology.org/ontology/PDQ/CDR0000037833 http://purl.bioontology.org/ontology/PDQ/CDR0000040986 http://purl.bioontology.org/ontology/PDQ/CDR0000271916 http://purl.bioontology.org/ontology/PDQ/CDR0000041598 http://purl.bioontology.org/ontology/PDQ/CDR0000041221 http://purl.bioontology.org/ontology/PDQ/CDR0000042395 http://purl.bioontology.org/ontology/PDQ/CDR0000042399 http://purl.bioontology.org/ontology/PDQ/CDR0000041495 http://purl.bioontology.org/ontology/PDQ/CDR0000039770 http://purl.bioontology.org/ontology/PDQ/CDR0000039619 http://purl.bioontology.org/ontology/PDQ/CDR0000041494 http://purl.bioontology.org/ontology/PDQ/CDR0000038284 http://purl.bioontology.org/ontology/PDQ/CDR0000041182 http://purl.bioontology.org/ontology/PDQ/CDR0000043106 http://purl.bioontology.org/ontology/PDQ/CDR0000043731 http://purl.bioontology.org/ontology/PDQ/CDR0000039519 http://purl.bioontology.org/ontology/PDQ/CDR0000039370 http://purl.bioontology.org/ontology/PDQ/CDR0000038481 http://purl.bioontology.org/ontology/PDQ/CDR0000040338 http://purl.bioontology.org/ontology/PDQ/CDR0000269773 http://purl.bioontology.org/ontology/PDQ/CDR0000040963 http://purl.bioontology.org/ontology/PDQ/CDR0000041315 http://purl.bioontology.org/ontology/PDQ/CDR0000042998 http://purl.bioontology.org/ontology/PDQ/CDR0000038397 http://purl.bioontology.org/ontology/PDQ/CDR0000038630 http://purl.bioontology.org/ontology/PDQ/CDR0000041128 http://purl.bioontology.org/ontology/PDQ/CDR0000039538 http://purl.bioontology.org/ontology/PDQ/CDR0000041232 http://purl.bioontology.org/ontology/PDQ/CDR0000038850 http://purl.bioontology.org/ontology/PDQ/CDR0000040407 http://purl.bioontology.org/ontology/PDQ/CDR0000306483 http://purl.bioontology.org/ontology/PDQ/CDR0000041734 http://purl.bioontology.org/ontology/PDQ/CDR0000368428 http://purl.bioontology.org/ontology/PDQ/CDR0000041978 http://purl.bioontology.org/ontology/PDQ/CDR0000041353 http://purl.bioontology.org/ontology/PDQ/CDR0000039192 http://purl.bioontology.org/ontology/PDQ/CDR0000039636 http://purl.bioontology.org/ontology/PDQ/CDR0000043726 http://purl.bioontology.org/ontology/PDQ/CDR0000039820 http://purl.bioontology.org/ontology/PDQ/CDR0000041826 http://purl.bioontology.org/ontology/PDQ/CDR0000040840 http://purl.bioontology.org/ontology/PDQ/CDR0000041526 http://purl.bioontology.org/ontology/PDQ/CDR0000039470 http://purl.bioontology.org/ontology/PDQ/CDR0000039316 http://purl.bioontology.org/ontology/PDQ/CDR0000042090 http://purl.bioontology.org/ontology/PDQ/CDR0000041894 http://purl.bioontology.org/ontology/PDQ/CDR0000041833 http://purl.bioontology.org/ontology/PDQ/CDR0000041035 http://purl.bioontology.org/ontology/PDQ/CDR0000039680 http://purl.bioontology.org/ontology/PDQ/CDR0000041222 http://purl.bioontology.org/ontology/PDQ/CDR0000043132 http://purl.bioontology.org/ontology/PDQ/CDR0000042350 http://purl.bioontology.org/ontology/PDQ/CDR0000041927 http://purl.bioontology.org/ontology/PDQ/CDR0000038981 http://purl.bioontology.org/ontology/PDQ/CDR0000041498 http://purl.bioontology.org/ontology/PDQ/CDR0000039063 http://purl.bioontology.org/ontology/PDQ/CDR0000038930 http://purl.bioontology.org/ontology/PDQ/CDR0000039596 http://purl.bioontology.org/ontology/PDQ/CDR0000040073 http://purl.bioontology.org/ontology/PDQ/CDR0000365677 http://purl.bioontology.org/ontology/PDQ/CDR0000038861 http://purl.bioontology.org/ontology/PDQ/CDR0000038556 http://purl.bioontology.org/ontology/PDQ/CDR0000041083 http://purl.bioontology.org/ontology/PDQ/CDR0000270390 http://purl.bioontology.org/ontology/PDQ/CDR0000041437 http://purl.bioontology.org/ontology/PDQ/CDR0000040285 http://purl.bioontology.org/ontology/PDQ/CDR0000039514 http://purl.bioontology.org/ontology/PDQ/CDR0000039346 http://purl.bioontology.org/ontology/PDQ/CDR0000350090 http://purl.bioontology.org/ontology/PDQ/CDR0000042413 http://purl.bioontology.org/ontology/PDQ/CDR0000041285 http://purl.bioontology.org/ontology/PDQ/CDR0000041905 http://purl.bioontology.org/ontology/PDQ/CDR0000043519 http://purl.bioontology.org/ontology/PDQ/CDR0000040655 http://purl.bioontology.org/ontology/PDQ/CDR0000039045 http://purl.bioontology.org/ontology/PDQ/CDR0000040075 http://purl.bioontology.org/ontology/PDQ/CDR0000041442 http://purl.bioontology.org/ontology/PDQ/CDR0000039778 http://purl.bioontology.org/ontology/PDQ/CDR0000037832 http://purl.bioontology.org/ontology/PDQ/CDR0000041790 http://purl.bioontology.org/ontology/PDQ/CDR0000039563 http://purl.bioontology.org/ontology/PDQ/CDR0000042462 http://purl.bioontology.org/ontology/PDQ/CDR0000040971 http://purl.bioontology.org/ontology/PDQ/CDR0000043218 http://purl.bioontology.org/ontology/PDQ/CDR0000039777 http://purl.bioontology.org/ontology/PDQ/CDR0000042397 http://purl.bioontology.org/ontology/PDQ/CDR0000042175 http://purl.bioontology.org/ontology/PDQ/CDR0000039107 http://purl.bioontology.org/ontology/PDQ/CDR0000040805 http://purl.bioontology.org/ontology/PDQ/CDR0000040280 http://purl.bioontology.org/ontology/PDQ/CDR0000038131 http://purl.bioontology.org/ontology/PDQ/CDR0000041235 http://purl.bioontology.org/ontology/PDQ/CDR0000042174 http://purl.bioontology.org/ontology/PDQ/CDR0000039513 http://purl.bioontology.org/ontology/PDQ/CDR0000043273 http://purl.bioontology.org/ontology/PDQ/CDR0000038482 http://purl.bioontology.org/ontology/PDQ/CDR0000039343 http://purl.bioontology.org/ontology/PDQ/CDR0000041129 http://purl.bioontology.org/ontology/PDQ/CDR0000038015 http://purl.bioontology.org/ontology/PDQ/CDR0000038400 http://purl.bioontology.org/ontology/PDQ/CDR0000038669 http://purl.bioontology.org/ontology/PDQ/CDR0000039696 http://purl.bioontology.org/ontology/PDQ/CDR0000037835 http://purl.bioontology.org/ontology/PDQ/CDR0000039520 http://purl.bioontology.org/ontology/PDQ/CDR0000040910 http://purl.bioontology.org/ontology/PDQ/CDR0000043005 http://purl.bioontology.org/ontology/PDQ/CDR0000041317 http://purl.bioontology.org/ontology/PDQ/CDR0000042097 http://purl.bioontology.org/ontology/PDQ/CDR0000041491 http://purl.bioontology.org/ontology/PDQ/CDR0000038309 http://purl.bioontology.org/ontology/PDQ/CDR0000040144 http://purl.bioontology.org/ontology/PDQ/CDR0000039645 http://purl.bioontology.org/ontology/PDQ/CDR0000040074 http://purl.bioontology.org/ontology/PDQ/CDR0000041329 http://purl.bioontology.org/ontology/PDQ/CDR0000038670 http://purl.bioontology.org/ontology/PDQ/CDR0000039345
cui	C1513197 C1513200 C1513212 C1513198 C1513201 C1513205 C1161371 C1513208 C0025677 C5441719 C1527140 C1513206 C1513211 C1513213 C1513202 C1527141 C1513203 C0591758 C0939510 C1513204 C1513214 C1513207 C1513210 C1513209
Date last modified	2018-03-01
definition	An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C642" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C642" NCI Thesaurus)
IND Code	7723 4291
Legacy PDQ ID	489
LT	TRD
NCI ID	C642
notation	CDR0000041719
NSC Code	740
ORIG STY	Drug/agent
prefLabel	methotrexate
tui	T109 T116 T121

Add comment

Add proposal

Subscribe to notes emails

Delete	Subject	Author	Type	Created
No notes to display

Create mapping

Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/RCD/x02iM	RCD	CUI
http://purl.bioontology.org/ontology/RXNORM/284900	RXNORM	CUI
http://purl.bioontology.org/ontology/SNMI/C-78170	SNMI	CUI
http://purl.bioontology.org/ontology/MESH/D008727	MESH	CUI
http://purl.bioontology.org/ontology/ATC/L01BA01	ATC	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000007370	NDFRT	CUI
http://purl.bioontology.org/ontology/ATC/L04AX03	ATC	CUI
http://purl.bioontology.org/ontology/SCTSPA/68887009	SCTSPA	CUI
http://purl.bioontology.org/ontology/RCD/h34..	RCD	CUI
http://purl.bioontology.org/ontology/MSHFRE/D008727	MSHFRE	CUI
http://purl.bioontology.org/ontology/VANDF/4019828	VANDF	CUI
http://purl.bioontology.org/ontology/LNC/LP16198-1	LOINC	CUI
http://purl.bioontology.org/ontology/CSP/1175-1202	CRISP	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147916	NDFRT	CUI
http://purl.bioontology.org/ontology/SCTSPA/387381009	SCTSPA	CUI
http://purl.bioontology.org/ontology/LNC/LA14339-8	LOINC	CUI
http://purl.bioontology.org/ontology/NDDF/002644	NDDF	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387381009	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/RXNORM/6851	RXNORM	CUI
http://purl.bioontology.org/ontology/LNC/MTHU005020	LOINC	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/68887009	SNOMEDCT	CUI
http://purl.obolibrary.org/obo/CHEBI_44185	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_44185	FYPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_44185	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_44185	GO-PLUS	LOOM
http://purl.obolibrary.org/obo/CHEBI_44185	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_44185	OBA	LOOM
http://purl.bioontology.org/ontology/SNMI/C-78170	SNMI	LOOM
http://www.semanticweb.org/dellvostro3750/ontologies/2018/2/untitled-ontology-10#methotrexate	HP_O	LOOM
http://purl.bioontology.org/ontology/MESH/D008727	MESH	LOOM
http://purl.bioontology.org/ontology/ATC/L01BA01	ATC	LOOM
http://purl.obolibrary.org/obo/CHEBI_44185	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_44185	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_44185	DINTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_44185	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_44185	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_44185	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_44185	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_44185	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_44185	ODNAE	LOOM
http://bmi.utah.edu/ontologies/peontology/C0025677	RAO	LOOM
http://purl.obolibrary.org/obo/OMIT_0009786	OMIT	LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02537	MIO	LOOM
http://purl.jp/bio/4/id/200906002710798892	IOBC	LOOM
http://purl.bioontology.org/ontology/ATC/L04AX03	ATC	LOOM
http://purl.bioontology.org/ontology/RCD/h34..	RCD	LOOM
http://stirdf.jst.go.jp/id/200907053089575288	IOBC	LOOM
http://purl.bioontology.org/ontology/VANDF/4019828	VANDF	LOOM
http://purl.bioontology.org/ontology/LNC/LP16198-1	LOINC	LOOM
http://purl.obolibrary.org/obo/NCIT_C642	BERO	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147916	ODAE	LOOM
http://www.drugbank.ca/drugs/DB00563	FTC	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C642	NCIT	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017772	PMAPP-PMO	LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00469	COID	LOOM
http://purl.bioontology.org/ontology/CSP/1175-1202	CRISP	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0025677	OCHV	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.733.631.192.500	RH-MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#8044	OCHV	LOOM
http://purl.org/obo/owl/CHEBI#CHEBI_44185	NPO	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147916	NDFRT	LOOM
http://purl.bioontology.org/ontology/LNC/LA14339-8	LOINC	LOOM
https://github.com/sap218/ocimido/blob/master/ontology/ocimido.owl#OCIMIDO_00181	OCIMIDO	LOOM
http://purl.obolibrary.org/obo/ARO_3007096	ARO	LOOM
http://localhost/plosthes.2017-1#5614	PLOSTHES	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008727	RH-MESH	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassb1cefdd0_4663_4764_90f3_d06fe0ae1d37	WWECA	LOOM
https://go.drugbank.com/drugs/DB00563	MDM	LOOM
http://purl.bioontology.org/ontology/NDDF/002644	NDDF	LOOM
http://purl.obolibrary.org/obo/MESH_D008727	BERO	LOOM
http://purl.obolibrary.org/obo/dinto_1762	DINTO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387381009	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/RXNORM/6851	RXNORM	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU005020	LOINC	LOOM
http://ontology.lst.tfo.upm.es/SPT/chemo#Cancer_Therapy_Agent_Name@@9	HENEGEO	LOOM
http://www.gamuts.net/entity#methotrexate	GAMUTS	LOOM
http://scai.fraunhofer.de/MSOntology#Methotrexate	MSO	LOOM
http://www.co-ode.org/ontologies/galen#Methotrexate	GALEN	LOOM