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Last uploaded: January 31, 2024

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Preferred Name	docetaxel
Synonyms	Docecad
Definitions	A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1526" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1526" NCI Thesaurus)
ID	http://purl.bioontology.org/ontology/PDQ/CDR0000041657
altLabel	Docecad RP 56976 RP56976 TXT [2aR-[2a alphaa,4beta,4a beta,6beta,9alpha,(alphaR,betaS),-11alpha,12alpha,12a alpha,12b alpha]]-beta-[[(1,1-dimethylethoxy)carbonyl]-amino]-alpha-hydroxybenzemepropanoic acid 12b-(Acetyloxy)-12(benzyloxy)-2a,3,4,4a,5,6,8,10,11,12,12a,12b-dodecahydeo-4,-6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Taxotere
CAS Registry	114977-28-5
Component of	http://purl.bioontology.org/ontology/PDQ/CDR0000042221 http://purl.bioontology.org/ontology/PDQ/CDR0000043150 http://purl.bioontology.org/ontology/PDQ/CDR0000405881 http://purl.bioontology.org/ontology/PDQ/CDR0000038527 http://purl.bioontology.org/ontology/PDQ/CDR0000352150 http://purl.bioontology.org/ontology/PDQ/CDR0000372907 http://purl.bioontology.org/ontology/PDQ/CDR0000037868 http://purl.bioontology.org/ontology/PDQ/CDR0000038122 http://purl.bioontology.org/ontology/PDQ/CDR0000388010 http://purl.bioontology.org/ontology/PDQ/CDR0000043335 http://purl.bioontology.org/ontology/PDQ/CDR0000042531 http://purl.bioontology.org/ontology/PDQ/CDR0000038302 http://purl.bioontology.org/ontology/PDQ/CDR0000037859 http://purl.bioontology.org/ontology/PDQ/CDR0000269485 http://purl.bioontology.org/ontology/PDQ/CDR0000377521 http://purl.bioontology.org/ontology/PDQ/CDR0000038366 http://purl.bioontology.org/ontology/PDQ/CDR0000357941 http://purl.bioontology.org/ontology/PDQ/CDR0000043643 http://purl.bioontology.org/ontology/PDQ/CDR0000043593 http://purl.bioontology.org/ontology/PDQ/CDR0000042813 http://purl.bioontology.org/ontology/PDQ/CDR0000257389 http://purl.bioontology.org/ontology/PDQ/CDR0000043499 http://purl.bioontology.org/ontology/PDQ/CDR0000355818 http://purl.bioontology.org/ontology/PDQ/CDR0000352178 http://purl.bioontology.org/ontology/PDQ/CDR0000038270 http://purl.bioontology.org/ontology/PDQ/CDR0000299071 http://purl.bioontology.org/ontology/PDQ/CDR0000423473 http://purl.bioontology.org/ontology/PDQ/CDR0000352014 http://purl.bioontology.org/ontology/PDQ/CDR0000443025 http://purl.bioontology.org/ontology/PDQ/CDR0000357873 http://purl.bioontology.org/ontology/PDQ/CDR0000042335 http://purl.bioontology.org/ontology/PDQ/CDR0000391173 http://purl.bioontology.org/ontology/PDQ/CDR0000389265 http://purl.bioontology.org/ontology/PDQ/CDR0000038667 http://purl.bioontology.org/ontology/PDQ/CDR0000042530 http://purl.bioontology.org/ontology/PDQ/CDR0000374992 http://purl.bioontology.org/ontology/PDQ/CDR0000037969 http://purl.bioontology.org/ontology/PDQ/CDR0000256467 http://purl.bioontology.org/ontology/PDQ/CDR0000043108 http://purl.bioontology.org/ontology/PDQ/CDR0000042539 http://purl.bioontology.org/ontology/PDQ/CDR0000334874 http://purl.bioontology.org/ontology/PDQ/CDR0000339958 http://purl.bioontology.org/ontology/PDQ/CDR0000355803 http://purl.bioontology.org/ontology/PDQ/CDR0000043229 http://purl.bioontology.org/ontology/PDQ/CDR0000038486 http://purl.bioontology.org/ontology/PDQ/CDR0000043257 http://purl.bioontology.org/ontology/PDQ/CDR0000038695 http://purl.bioontology.org/ontology/PDQ/CDR0000322262 http://purl.bioontology.org/ontology/PDQ/CDR0000038545 http://purl.bioontology.org/ontology/PDQ/CDR0000043383 http://purl.bioontology.org/ontology/PDQ/CDR0000393518 http://purl.bioontology.org/ontology/PDQ/CDR0000430107 http://purl.bioontology.org/ontology/PDQ/CDR0000343780 http://purl.bioontology.org/ontology/PDQ/CDR0000271334 http://purl.bioontology.org/ontology/PDQ/CDR0000043014 http://purl.bioontology.org/ontology/PDQ/CDR0000042151 http://purl.bioontology.org/ontology/PDQ/CDR0000422409 http://purl.bioontology.org/ontology/PDQ/CDR0000437138 http://purl.bioontology.org/ontology/PDQ/CDR0000368454 http://purl.bioontology.org/ontology/PDQ/CDR0000038668 http://purl.bioontology.org/ontology/PDQ/CDR0000038365 http://purl.bioontology.org/ontology/PDQ/CDR0000420970 http://purl.bioontology.org/ontology/PDQ/CDR0000409702 http://purl.bioontology.org/ontology/PDQ/CDR0000038480 http://purl.bioontology.org/ontology/PDQ/CDR0000038684 http://purl.bioontology.org/ontology/PDQ/CDR0000269167 http://purl.bioontology.org/ontology/PDQ/CDR0000043347 http://purl.bioontology.org/ontology/PDQ/CDR0000357560 http://purl.bioontology.org/ontology/PDQ/CDR0000386169 http://purl.bioontology.org/ontology/PDQ/CDR0000042701 http://purl.bioontology.org/ontology/PDQ/CDR0000334947 http://purl.bioontology.org/ontology/PDQ/CDR0000043486 http://purl.bioontology.org/ontology/PDQ/CDR0000357522 http://purl.bioontology.org/ontology/PDQ/CDR0000361542 http://purl.bioontology.org/ontology/PDQ/CDR0000043062 http://purl.bioontology.org/ontology/PDQ/CDR0000038303 http://purl.bioontology.org/ontology/PDQ/CDR0000038209 http://purl.bioontology.org/ontology/PDQ/CDR0000358327 http://purl.bioontology.org/ontology/PDQ/CDR0000256414 http://purl.bioontology.org/ontology/PDQ/CDR0000442106 http://purl.bioontology.org/ontology/PDQ/CDR0000420843 http://purl.bioontology.org/ontology/PDQ/CDR0000358199 http://purl.bioontology.org/ontology/PDQ/CDR0000037838 http://purl.bioontology.org/ontology/PDQ/CDR0000042962 http://purl.bioontology.org/ontology/PDQ/CDR0000038493 http://purl.bioontology.org/ontology/PDQ/CDR0000437254 http://purl.bioontology.org/ontology/PDQ/CDR0000378336 http://purl.bioontology.org/ontology/PDQ/CDR0000042336 http://purl.bioontology.org/ontology/PDQ/CDR0000042633 http://purl.bioontology.org/ontology/PDQ/CDR0000037836 http://purl.bioontology.org/ontology/PDQ/CDR0000037906 http://purl.bioontology.org/ontology/PDQ/CDR0000038699 http://purl.bioontology.org/ontology/PDQ/CDR0000257137 http://purl.bioontology.org/ontology/PDQ/CDR0000380852 http://purl.bioontology.org/ontology/PDQ/CDR0000038075 http://purl.bioontology.org/ontology/PDQ/CDR0000352013 http://purl.bioontology.org/ontology/PDQ/CDR0000445459 http://purl.bioontology.org/ontology/PDQ/CDR0000043382 http://purl.bioontology.org/ontology/PDQ/CDR0000315653 http://purl.bioontology.org/ontology/PDQ/CDR0000038449 http://purl.bioontology.org/ontology/PDQ/CDR0000358058 http://purl.bioontology.org/ontology/PDQ/CDR0000306450 http://purl.bioontology.org/ontology/PDQ/CDR0000038346 http://purl.bioontology.org/ontology/PDQ/CDR0000038710 http://purl.bioontology.org/ontology/PDQ/CDR0000353339 http://purl.bioontology.org/ontology/PDQ/CDR0000358333 http://purl.bioontology.org/ontology/PDQ/CDR0000288842 http://purl.bioontology.org/ontology/PDQ/CDR0000258338 http://purl.bioontology.org/ontology/PDQ/CDR0000445418 http://purl.bioontology.org/ontology/PDQ/CDR0000037931 http://purl.bioontology.org/ontology/PDQ/CDR0000037876 http://purl.bioontology.org/ontology/PDQ/CDR0000330214 http://purl.bioontology.org/ontology/PDQ/CDR0000038364 http://purl.bioontology.org/ontology/PDQ/CDR0000368788 http://purl.bioontology.org/ontology/PDQ/CDR0000038267 http://purl.bioontology.org/ontology/PDQ/CDR0000322130 http://purl.bioontology.org/ontology/PDQ/CDR0000410774 http://purl.bioontology.org/ontology/PDQ/CDR0000372886 http://purl.bioontology.org/ontology/PDQ/CDR0000415310 http://purl.bioontology.org/ontology/PDQ/CDR0000373961
cui	C0733872 C0246415 C4087017 C0771375 C0699967
Date last modified	2018-03-01
definition	A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1526" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1526" NCI Thesaurus)
IND Code	40466
Legacy PDQ ID	4819
LT	TRD
NCI ID	C1526
notation	CDR0000041657
NSC Code	628503
ORIG STY	Drug/agent
prefLabel	docetaxel
tui	T109 T121

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/MSHFRE/D000077143	MSHFRE	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148441	NDFRT	CUI
http://purl.bioontology.org/ontology/MSHFRE/D000077143	MSHFRE	CUI
http://purl.bioontology.org/ontology/CSP/0093-3150	CRISP	CUI
http://purl.bioontology.org/ontology/MESH/D000077143	MESH	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/108806006	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/MSHFRE/D000077143	MSHFRE	CUI
http://purl.bioontology.org/ontology/CSP/0093-3150	CRISP	CUI
http://purl.bioontology.org/ontology/MESH/D000077143	MESH	CUI
http://purl.bioontology.org/ontology/ATC/L01CD02	ATC	CUI
http://purl.bioontology.org/ontology/SCTSPA/108806006	SCTSPA	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000005739	NDFRT	CUI
http://purl.bioontology.org/ontology/RCD/h5E..	RCD	CUI
http://purl.bioontology.org/ontology/VANDF/4020968	VANDF	CUI
http://purl.bioontology.org/ontology/NDDF/005187	NDDF	CUI
http://purl.bioontology.org/ontology/SCTSPA/386918005	SCTSPA	CUI
http://purl.bioontology.org/ontology/RXNORM/72962	RXNORM	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/386918005	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/MESH/D000077143	MESH	CUI
http://purl.bioontology.org/ontology/RXNORM/1299922	RXNORM	CUI
http://purl.bioontology.org/ontology/NDDF/005188	NDDF	CUI
http://purl.bioontology.org/ontology/MESH/D000077143	MESH	CUI
http://purl.bioontology.org/ontology/RXNORM/202982	RXNORM	CUI
http://purl.bioontology.org/ontology/RCD/x03cn	RCD	CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C067311	RH-MESH	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148441	NDFRT	LOOM
http://ontology.lst.tfo.upm.es/BD2D/chemo#Cancer_Therapy_Agent_Name@@4	HENECON	LOOM
http://purl.jp/bio/4/id/200906091109109292	IOBC	LOOM
http://www.semanticweb.org/hx-jta/ontologies/thyroid_cancer_ontology#Docetaxel	TCO	LOOM
http://purl.obolibrary.org/obo/NCIT_C1526	BERO	LOOM
http://purl.bioontology.org/ontology/MESH/D000077143	MESH	LOOM
http://www.drugbank.ca/drugs/DB01248	FTC	LOOM
http://stirdf.jst.go.jp/id/200907094393798330	IOBC	LOOM
http://www.semanticweb.org/MGB/ontologies/MGBD#Docetaxel	MGBD	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#25141	OCHV	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148441	ODAE	LOOM
http://purl.bioontology.org/ontology/ATC/L01CD02	ATC	LOOM
http://www.co-ode.org/ontologies/galen#Docetaxel	GALEN	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0246415	OCHV	LOOM
http://purl.bioontology.org/ontology/RCD/h5E..	RCD	LOOM
http://purl.bioontology.org/ontology/VANDF/4020968	VANDF	LOOM
http://purl.bioontology.org/ontology/NDDF/005187	NDDF	LOOM
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Docetaxel	PCAO	LOOM
http://purl.bioontology.org/ontology/RXNORM/72962	RXNORM	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526	NCIT	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526	ROO	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026277	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386918005	SNOMEDCT	LOOM
https://go.drugbank.com/drugs/DB01248	MDM	LOOM
http://www.ifomis.org/acgt/1.0#Docetaxel	ACGT-MO	LOOM