Preferred Name |
quinine |
|
Synonyms |
QUIN |
|
Definitions |
A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C794" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C794" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000041253 |
|
altLabel |
QUIN |
|
CAS Registry |
130-95-0 |
|
Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000041475 http://purl.bioontology.org/ontology/PDQ/CDR0000041262 http://purl.bioontology.org/ontology/PDQ/CDR0000041846 |
|
cui |
C0034417 |
|
definition |
A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C794" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C794" NCI Thesaurus) |
|
Legacy PDQ ID |
4326 |
|
NCI ID |
C794 |
|
notation |
CDR0000041253 |
|
NSC Code |
192949 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
quinine |
|
tui |
T109 T121 |