Physician Data Query

Last uploaded: November 18, 2019
Preferred Name

ibuprofen

Synonyms

benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-

Definitions

A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C561" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C561" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000040475

altLabel

benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-

Motrin

p-isobutylhydratropic acid

CAS Registry

15687-27-1

cui

C0020740

C0699203

definition

A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C561" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C561" NCI Thesaurus)

Legacy PDQ ID

3359

LT

TRD

NCI ID

C561

notation

CDR0000040475

NSC Code

256857

ORIG STY

Drug/agent

prefLabel

ibuprofen

tui

T109

T121

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http://purl.jp/bio/4/id/200906004759097752 IOBC LOOM
http://www.semanticweb.org/席婷/ontologies/2019/3/untitled-ontology-62#Ibuprofen PCALION LOOM
http://purl.jp/bio/4/id/200906005183226949 IOBC LOOM
http://www.drugbank.ca/drugs/DB01050 FTC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C561 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C561 NCIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D007052 RH-MESH LOOM
http://scai.fraunhofer.de/AlzheimerOntology#Ibuprofen ADO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/38268001 SNOMEDCT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146197 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146197 NDFRT LOOM
http://purl.bioontology.org/ontology/SCTSPA/387207008 SCTSPA CUI
http://stirdf.jst.go.jp/id/200907012240750528 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387207008 SNOMEDCT CUI
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http://purl.bioontology.org/ontology/UATC/M01AE01 ATC CUI
http://purl.bioontology.org/ontology/UATC/M01AE01 ATC LOOM
http://purl.bioontology.org/ontology/UATC/C01EB16 ATC CUI
http://purl.bioontology.org/ontology/UATC/C01EB16 ATC LOOM
http://purl.bioontology.org/ontology/CSP/2270-2077 CRISP CUI
http://purl.bioontology.org/ontology/CSP/2270-2077 CRISP LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 HUPSON LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 NIFSTD LOOM
http://purl.bioontology.org/ontology/SNMI/C-603C0 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-603C0 SNMI LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004262 LOINC CUI
http://purl.bioontology.org/ontology/LNC/MTHU004262 LOINC LOOM
http://purl.bioontology.org/ontology/UATC/M02AA13 ATC CUI
http://purl.bioontology.org/ontology/UATC/M02AA13 ATC LOOM
http://purl.bioontology.org/ontology/VANDF/4017840 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4017840 VANDF LOOM
http://stirdf.jst.go.jp/id/200907069737148009 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/002377 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/002377 NDDF LOOM
http://purl.bioontology.org/ontology/MSHFRE/D007052 MSHFRE CUI
http://www.co-ode.org/ontologies/galen#Ibuprofen GALEN LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6519 OCHV LOOM
http://purl.bioontology.org/ontology/LNC/LP16165-0 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LP16165-0 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/LA14347-1 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LA14347-1 LOINC LOOM
http://purl.bioontology.org/ontology/RCD/x02MO RCD CUI
http://purl.bioontology.org/ontology/MESH/D007052 MESH CUI
http://purl.bioontology.org/ontology/MESH/D007052 MESH CUI
http://purl.bioontology.org/ontology/MESH/D007052 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0020740 OCHV LOOM
http://purl.bioontology.org/ontology/UATC/R02AX02 ATC CUI
http://purl.bioontology.org/ontology/UATC/R02AX02 ATC LOOM
http://www.projecthalo.com/aura#Ibuprofen AURA LOOM
http://purl.bioontology.org/ontology/RCD/x02jz RCD CUI
http://scdontology.h3abionet.org/ontology/SCDO_0000606 SCDO LOOM
http://purl.bioontology.org/ontology/RXNORM/202488 RXNORM CUI
http://purl.bioontology.org/ontology/UATC/G02CC01 ATC CUI
http://purl.bioontology.org/ontology/UATC/G02CC01 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/5640 RXNORM CUI
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http://purl.bioontology.org/ontology/NDFRT/N0000006993 NDFRT CUI
http://purl.bioontology.org/ontology/SCTSPA/38268001 SCTSPA CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.223.701.430 RH-MESH LOOM