floxuridine

floxuridin

A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthetase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C504" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C504" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000039242

floxuridin

FUdR

1-(2-deoxy-beta-D-ribofuranosyl)-5-fluorouracil

5-fluoro-2'-deoxyuridine

5FUDR

WR-138720

fluoruridine deoxyribose

5-fluorouracil deoxyriboside

2'-deoxy-5-fluorouridine

fluorodeoxyuridine

2-deoxy-5-fluorouridine

5-fluorodeoxyuridine

FdUrD

FDUR

5-fluorouridine deoxyribose

fluorouridine deoxyribose

5-FUDR

FUDF

5-fluoro-2'-deoxy-beta-uridine

50-91-9

http://purl.bioontology.org/ontology/PDQ/CDR0000042898

http://purl.bioontology.org/ontology/PDQ/CDR0000041808

http://purl.bioontology.org/ontology/PDQ/CDR0000038874

http://purl.bioontology.org/ontology/PDQ/CDR0000042900

http://purl.bioontology.org/ontology/PDQ/CDR0000039125

http://purl.bioontology.org/ontology/PDQ/CDR0000041986

http://purl.bioontology.org/ontology/PDQ/CDR0000042899

http://purl.bioontology.org/ontology/PDQ/CDR0000040476

http://purl.bioontology.org/ontology/PDQ/CDR0000041677

http://purl.bioontology.org/ontology/PDQ/CDR0000037988

http://purl.bioontology.org/ontology/PDQ/CDR0000043338

http://purl.bioontology.org/ontology/PDQ/CDR0000040335

http://purl.bioontology.org/ontology/PDQ/CDR0000041772

http://purl.bioontology.org/ontology/PDQ/CDR0000041961

http://purl.bioontology.org/ontology/PDQ/CDR0000041216

http://purl.bioontology.org/ontology/PDQ/CDR0000039124

http://purl.bioontology.org/ontology/PDQ/CDR0000041250

http://purl.bioontology.org/ontology/PDQ/CDR0000042337

http://purl.bioontology.org/ontology/PDQ/CDR0000043143

http://purl.bioontology.org/ontology/PDQ/CDR0000039652

http://purl.bioontology.org/ontology/PDQ/CDR0000041284

http://purl.bioontology.org/ontology/PDQ/CDR0000038176

http://purl.bioontology.org/ontology/PDQ/CDR0000041603

http://purl.bioontology.org/ontology/PDQ/CDR0000041818

http://purl.bioontology.org/ontology/PDQ/CDR0000315748

http://purl.bioontology.org/ontology/PDQ/CDR0000042782

http://purl.bioontology.org/ontology/PDQ/CDR0000043596

http://purl.bioontology.org/ontology/PDQ/CDR0000041987

http://purl.bioontology.org/ontology/PDQ/CDR0000041821

http://purl.bioontology.org/ontology/PDQ/CDR0000041279

C1517215

C0016343

C1522361

C3495433

2006-08-02

A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthetase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C504" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C504" NCI Thesaurus)

947

1864

TRD

C504

CDR0000039242

27640

Drug/agent

floxuridine

T114

T121