| Definitions |
The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C665" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C665" NCI Thesaurus)
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| altLabel |
1,3-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione Neotalem Onkotrone mitoxantrone dihydrochloride DHAD Mitroxone CL 232315 dihydroxyanthracenedione dihydrochloride CL 232,315 Pralifan DHAQ mitoxantrone HCl mitozantrone dihydroxyanthracenedione 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone
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