Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

alemtuzumab

Synonyms

Monoclonal Antibody Campath-1H

Definitions

A recombinant DNA-derived humanized monoclonal antibody directed against the cell surface glycoprotein CD52. Alemtuzumab is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions derived from a rat monoclonal antibody. This agent selectively binds to CD52, thereby triggering a host immune response that results in lysis of CD52 + cells. CD52 is a glycoprotein expressed on the surface of essentially all normal and malignant B and T cells, a majority of monocytes, macrophages and natural killer (NK) cells, a subpopulation of granulocytes, and tissues of the male reproductive system. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1681" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1681" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000037783

altLabel

Monoclonal Antibody Campath-1H

MabCampath

Monoclonal Antibody CD52

Campath

Campath-1H

anti-CD52 monoclonal antibody

MoAb CD52

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000365542

http://purl.bioontology.org/ontology/PDQ/CDR0000257897

http://purl.bioontology.org/ontology/PDQ/CDR0000420822

http://purl.bioontology.org/ontology/PDQ/CDR0000355733

http://purl.bioontology.org/ontology/PDQ/CDR0000340973

http://purl.bioontology.org/ontology/PDQ/CDR0000380935

http://purl.bioontology.org/ontology/PDQ/CDR0000429484

http://purl.bioontology.org/ontology/PDQ/CDR0000038585

http://purl.bioontology.org/ontology/PDQ/CDR0000361789

http://purl.bioontology.org/ontology/PDQ/CDR0000038487

cui

C1178562

C0939276

C0383429

C1271482

Date last modified

2006-07-26

definition

A recombinant DNA-derived humanized monoclonal antibody directed against the cell surface glycoprotein CD52. Alemtuzumab is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions derived from a rat monoclonal antibody. This agent selectively binds to CD52, thereby triggering a host immune response that results in lysis of CD52 + cells. CD52 is a glycoprotein expressed on the surface of essentially all normal and malignant B and T cells, a majority of monocytes, macrophages and natural killer (NK) cells, a subpopulation of granulocytes, and tissues of the male reproductive system. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1681" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1681" NCI Thesaurus)

IND Code

10864

Legacy PDQ ID

10139

LT

TRD

NCI ID

C1681

notation

CDR0000037783

NSC Code

715969

ORIG STY

Drug/agent

prefLabel

alemtuzumab

tui

T109

T116

T129

T121

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/MESH/D000074323 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000074323 MESH CUI
http://purl.bioontology.org/ontology/SNOMEDCT/129472003 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MSHFRE/D000074323 MSHFRE CUI
http://purl.bioontology.org/ontology/RXNORM/284679 RXNORM CUI
http://purl.bioontology.org/ontology/MSHFRE/D000074323 MSHFRE CUI
http://purl.bioontology.org/ontology/RXNORM/117055 RXNORM CUI
http://purl.bioontology.org/ontology/SCTSPA/391632007 SCTSPA CUI
http://purl.bioontology.org/ontology/NDDF/009169 NDDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/391632007 SNOMEDCT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148705 NDFRT CUI
http://purl.bioontology.org/ontology/MESH/D000074323 MESH CUI
http://purl.bioontology.org/ontology/MSHFRE/D000074323 MSHFRE CUI
http://purl.bioontology.org/ontology/NDFRT/N0000010039 NDFRT CUI
http://purl.bioontology.org/ontology/ATC/L04AA34 ATC CUI
http://purl.bioontology.org/ontology/VANDF/4021265 VANDF CUI
http://purl.bioontology.org/ontology/SCTSPA/129472003 SCTSPA CUI
http://purl.bioontology.org/ontology/SNOMEDCT/129472003 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0383429 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/117055 RXNORM LOOM
http://scai.fraunhofer.de/MSOntology#Alemtuzumab MSO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1681 NCIT LOOM
http://purl.obolibrary.org/obo/NCIT_C1681 BERO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148705 NDFRT LOOM
http://purl.bioontology.org/ontology/MESH/D000074323 MESH LOOM
https://go.drugbank.com/drugs/DB00087 MDM LOOM
http://www.drugbank.ca/drugs/DB00087 FTC LOOM
http://purl.jp/bio/4/id/200906076648240727 IOBC LOOM
http://purl.obolibrary.org/obo/DRON_00013634 PDRO LOOM
http://purl.obolibrary.org/obo/DRON_00013634 DRON LOOM
http://purl.bioontology.org/ontology/ATC/L04AA34 ATC LOOM
http://purl.bioontology.org/ontology/VANDF/4021265 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C096529 RH-MESH LOOM
http://purl.obolibrary.org/obo/dinto_DB00087 DINTO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00022046 PMAPP-PMO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#31929 OCHV LOOM