Physician Data Query

Last uploaded: August 28, 2024
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Preferred Name

benralizumab
Synonyms

MEDI-563

BIW-8405

anti-CD125 humanized monoclonal antibody, IgG1-kappa

KHK-4563
Definitions

An afucosylated, humanized monoclonal antibody against the alpha chain of the interleukin-5 receptor (IL-5Ra), with potential anti-asthmatic activity. Upon administration, benralizumab binds to IL-5Ra and elicits an antibody-directed cell cytotoxicity (ADCC) against IL-5Ra-expressing cells. This induces apoptosis in IL-5Ra-expressing cells and may reduce asthmatic episodes. IL-5Ra, expressed on both eosinophils and basophils, plays a key role in asthma. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C88594" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C88594" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000794137
altLabel

MEDI-563

BIW-8405

anti-CD125 humanized monoclonal antibody, IgG1-kappa

KHK-4563
CAS Registry

1044511-01-4
cui

C4521110

C4521111

C2982078

C4521109
DATE FIRST PUBLISHED

2018-07-27
Date last modified

2018-07-27
definition

An afucosylated, humanized monoclonal antibody against the alpha chain of the interleukin-5 receptor (IL-5Ra), with potential anti-asthmatic activity. Upon administration, benralizumab binds to IL-5Ra and elicits an antibody-directed cell cytotoxicity (ADCC) against IL-5Ra-expressing cells. This induces apoptosis in IL-5Ra-expressing cells and may reduce asthmatic episodes. IL-5Ra, expressed on both eosinophils and basophils, plays a key role in asthma. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C88594" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C88594" NCI Thesaurus)
NCI ID

C88594
notation

CDR0000794137
ORIG STY

Drug/agent
prefLabel

benralizumab
tui

T116

T129

T121
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Mapping To Ontology Source
http://purl.bioontology.org/ontology/MESH/C571386 MESH CUI
http://purl.bioontology.org/ontology/MESH/C571386 MESH CUI
http://purl.bioontology.org/ontology/SCTSPA/763651005 SCTSPA CUI
http://purl.bioontology.org/ontology/SCTSPA/763652003 SCTSPA CUI
http://purl.bioontology.org/ontology/NDDF/017409 NDDF CUI
http://purl.bioontology.org/ontology/VANDF/4037103 VANDF CUI
http://purl.bioontology.org/ontology/MESH/C571386 MESH CUI
http://purl.bioontology.org/ontology/SNOMEDCT/763651005 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/763652003 SNOMEDCT CUI
http://purl.bioontology.org/ontology/ATC/R03DX10 ATC CUI
http://purl.bioontology.org/ontology/RXNORM/1989100 RXNORM CUI
http://purl.bioontology.org/ontology/NDFRT/N0000193718 NDFRT CUI
http://purl.obolibrary.org/obo/DRON_00803390 DRON LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C571386 RH-MESH LOOM
http://purl.obolibrary.org/obo/NCIT_C88594 BERO LOOM
http://purl.bioontology.org/ontology/NDDF/017409 NDDF LOOM
http://purl.bioontology.org/ontology/VANDF/4037103 VANDF LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C88594 NCIT LOOM
http://purl.bioontology.org/ontology/MESH/C571386 MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/763651005 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/DRON_00803390 PDRO LOOM
http://purl.obolibrary.org/obo/DRON_00803390 DDSS LOOM
http://purl.bioontology.org/ontology/ATC/R03DX10 ATC LOOM
https://go.drugbank.com/drugs/DB12023 MDM LOOM
http://purl.bioontology.org/ontology/RXNORM/1989100 RXNORM LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000193718 NDFRT LOOM