Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

trimetazidine

Synonyms

Vastarel MR

Definitions

An orally available small molecule compound with anti-ischemic, and potential immunomodulating and antineoplastic properties. Although its exact mechanism is not yet fully elucidated, it is postulated that upon administration, trimetazidine selectively inhibits long-chain 3-ketoacyl coenzyme A thiolase (LC 3-KAT), the final enzyme in the free fatty acid (FFA) beta-oxidation pathway. This stimulates glucose oxidation, which requires less oxygen usage and cellular energy than in the beta-oxidation process. This optimizes myocardial energy metabolism and cardiac functioning in an ischemic condition. In cancer cells, the inhibition of fatty acid oxidation (FAO) alters the metabolic processes needed for tumor cell function and proliferation, thereby inducing tumor cell apoptosis. In addition, inhibition of FAO may potentially block the immunosuppressive functions of myeloid-derived suppressor cells (MSDCs), which are thought to promote malignant cell proliferation and migration by inhibiting T-cell function. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C76590" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C76590" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000793610

altLabel

Vastarel MR

CAS Registry

5011-34-7

cui

C2700080

C0041037

DATE FIRST PUBLISHED

2018-06-13

Date last modified

2018-07-19

definition

An orally available small molecule compound with anti-ischemic, and potential immunomodulating and antineoplastic properties. Although its exact mechanism is not yet fully elucidated, it is postulated that upon administration, trimetazidine selectively inhibits long-chain 3-ketoacyl coenzyme A thiolase (LC 3-KAT), the final enzyme in the free fatty acid (FFA) beta-oxidation pathway. This stimulates glucose oxidation, which requires less oxygen usage and cellular energy than in the beta-oxidation process. This optimizes myocardial energy metabolism and cardiac functioning in an ischemic condition. In cancer cells, the inhibition of fatty acid oxidation (FAO) alters the metabolic processes needed for tumor cell function and proliferation, thereby inducing tumor cell apoptosis. In addition, inhibition of FAO may potentially block the immunosuppressive functions of myeloid-derived suppressor cells (MSDCs), which are thought to promote malignant cell proliferation and migration by inhibiting T-cell function. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C76590" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C76590" NCI Thesaurus)

LT

TRD

NCI ID

C76590

notation

CDR0000793610

ORIG STY

Drug/agent

prefLabel

trimetazidine

tui

T109

T121

Delete Subject Author Type Created
No notes to display
Create mapping

Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/RXNORM/10826 RXNORM CUI
http://purl.bioontology.org/ontology/MSHFRE/D014292 MSHFRE CUI
http://purl.bioontology.org/ontology/SNOMEDCT/1156140000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/ATC/C01EB15 ATC CUI
http://purl.bioontology.org/ontology/NDDF/003771 NDDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/703365009 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MESH/D014292 MESH CUI
http://purl.bioontology.org/ontology/NDFRT/N0000167121 NDFRT CUI
http://purl.bioontology.org/ontology/SCTSPA/703365009 SCTSPA CUI
http://purl.bioontology.org/ontology/SCTSPA/1156140000 SCTSPA CUI
http://purl.bioontology.org/ontology/RXNORM/10826 RXNORM LOOM
http://purl.jp/bio/4/id/200906062124915041 IOBC LOOM
http://purl.obolibrary.org/obo/OMIT_0015130 OMIT LOOM
https://go.drugbank.com/drugs/DB09069 MDM LOOM
http://purl.obolibrary.org/obo/MESH_D014292 BERO LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02171 MIO LOOM
http://stirdf.jst.go.jp/id/200907002463929079 IOBC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018276 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/ATC/C01EB15 ATC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/703365009 SNOMEDCT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76590 NCIT LOOM
http://purl.bioontology.org/ontology/MESH/D014292 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12570 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.606.920 RH-MESH LOOM
http://bmi.utah.edu/ontologies/hfontology/C0041037 HFO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014292 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0041037 OCHV LOOM
http://purl.obolibrary.org/obo/NCIT_C76590 BERO LOOM
http://purl.obolibrary.org/obo/DRON_00016031 PDRO LOOM
http://purl.obolibrary.org/obo/DRON_00016031 DRON LOOM