loading...| Preferred Name |
methylnaltrexone bromide |
|
| Synonyms |
Relistor |
|
| Definitions |
The bromide salt form of methylnaltrexone, a methyl derivative of noroxymorphone with selective, peripherally-acting mu-opioid receptor antagonistic activity. Methylnaltrexone displaces opioids from peripheral opioid receptors in the gastrointestinal tract, the bladder, and the skin, thereby reversing the opioid-related peripheral side-effects, such as constipation, urinary retention, and pruritis, respectively. Unlike naltrexone and due to the presence of a positively charged nitrogen atom in methylnaltrexone, this agent does not cross the blood-brain barrier and does not affect the centrally-mediated analgesic effect of opioids. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C80569" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C80569" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000786490 |
|
| altLabel |
Relistor |
|
| CAS Registry |
73232-52-7 |
|
| cui |
C2343921 C2343585 |
|
| DATE FIRST PUBLISHED |
2017-01-26 |
|
| Date last modified |
2017-01-26 |
|
| definition |
The bromide salt form of methylnaltrexone, a methyl derivative of noroxymorphone with selective, peripherally-acting mu-opioid receptor antagonistic activity. Methylnaltrexone displaces opioids from peripheral opioid receptors in the gastrointestinal tract, the bladder, and the skin, thereby reversing the opioid-related peripheral side-effects, such as constipation, urinary retention, and pruritis, respectively. Unlike naltrexone and due to the presence of a positively charged nitrogen atom in methylnaltrexone, this agent does not cross the blood-brain barrier and does not affect the centrally-mediated analgesic effect of opioids. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C80569" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C80569" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C80569 |
|
| notation |
CDR0000786490 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
methylnaltrexone bromide |
|
| tui |
T109 T121 |