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Physician Data Query
| Id | http://purl.bioontology.org/ontology/PDQ/CDR0000783856
http://purl.bioontology.org/ontology/PDQ/CDR0000783856
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|---|---|
| Preferred Name | carnosine |
| Definitions |
A dipeptide comprised of a beta-alanine and a 3-methyl-L-histidine, which is found in dietary red meat, with potential antioxidant, metal-chelating and anti-glycation activities. Carnosine scavenges both reactive oxygen species (ROS) and unsaturated aldehydes produced by cell membrane lipid peroxidation. Additionally, this dipeptide may reduce the rate of formation of advanced glycation end-products (AGE). Altogether, this may protect cells against oxidative damage. In addition, carnosine is able to chelate toxic metals. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C118880" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C118880" NCI Thesaurus)
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| Synonyms |
beta-alanylhistidine
L-histidine, N-beta-alanyl-
L-histidine, beta-alanyl-
(2S)-2-[(3-amino-1-oxopropyl)Amino]-3-(3H-imidazol-4-Yl)propanoic acid
beta-alanyl-L-histidine
L-carnosine
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A dipeptide comprised of a beta-alanine and a 3-methyl-L-histidine, which is found in dietary red meat, with potential antioxidant, metal-chelating and anti-glycation activities. Carnosine scavenges both reactive oxygen species (ROS) and unsaturated aldehydes produced by cell membrane lipid peroxidation. Additionally, this dipeptide may reduce the rate of formation of advanced glycation end-products (AGE). Altogether, this may protect cells against oxidative damage. In addition, carnosine is able to chelate toxic metals. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C118880" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C118880" NCI Thesaurus) |
|---|---|
| altLabel |
beta-alanylhistidine
L-histidine, N-beta-alanyl-
L-histidine, beta-alanyl-
(2S)-2-[(3-amino-1-oxopropyl)Amino]-3-(3H-imidazol-4-Yl)propanoic acid
beta-alanyl-L-histidine
L-carnosine
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| prefLabel | carnosine
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| CAS Registry | 305-84-0
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| notation | CDR0000783856
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| ORIG STY | Drug/agent
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| Date last modified | 2017-06-09
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| Semantic type UMLS property | |
| NCI ID | C118880
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| type | |
| tui |
T116
T123
T121
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| DATE FIRST PUBLISHED | 2016-09-26
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| cui | C0007267
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