loading...| Preferred Name |
divalproex sodium |
|
| Synonyms |
sodium divalproex Depakote Depacon Valparin sodium hydrogen bis(2-propylpentanoate) Epilex valproate semisodium Abbott 50711 Depakote ER Epival |
|
| Definitions |
A stable coordination compound comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Divalproex dissociates to the valproate ion in the gastrointestinal tract. This agent binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Divalproex may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28996" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28996" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000778070 |
|
| altLabel |
sodium divalproex Depakote Depacon Valparin sodium hydrogen bis(2-propylpentanoate) Epilex valproate semisodium Abbott 50711 Depakote ER Epival |
|
| CAS Registry |
76584-70-8 |
|
| cui |
C2987577 C2699792 C2699791 C0939309 C2987459 C0719750 C0886883 C0719751 |
|
| DATE FIRST PUBLISHED |
2016-01-14 |
|
| Date last modified |
2016-01-14 |
|
| definition |
A stable coordination compound comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Divalproex dissociates to the valproate ion in the gastrointestinal tract. This agent binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Divalproex may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28996" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28996" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C28996 |
|
| notation |
CDR0000778070 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
divalproex sodium |
|
| tui |
T109 T121 |