loading...| Preferred Name |
topical fluorouracil |
|
| Synonyms |
Flurox Cytosafe Timazin Fluoroplex Carac topical 5-fluorouracil Arumel Fiverocil 5-FU topical topical 5FU Efudex Efurix Actino-Hermal Tolak |
|
| Definitions |
A topical formulation containing the antimetabolite 5-fluorouracil (5-FU), with antineoplastic activity. Upon topical administration, 5-FU is converted into the active metabolite 5-fluoroxyuridine monophosphate (F-UMP), which competes with uracil during RNA synthesis and inhibits RNA processing. Conversion of 5-FU into another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase; this results in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in DNA synthesis, and thus inhibits DNA synthesis. Altogether, this prevents the proliferation of tumor cells locally. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C125194" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C125194" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000777929 |
|
| altLabel |
Flurox Cytosafe Timazin Fluoroplex Carac topical 5-fluorouracil Arumel Fiverocil 5-FU topical topical 5FU Efudex Efurix Actino-Hermal Tolak |
|
| CAS Registry |
51-21-8 |
|
| cui |
C1527295 C0699375 C1517226 C3215191 C1517233 C4056538 C1517227 C1517225 C1517224 C0939777 C0699372 C1517228 |
|
| DATE FIRST PUBLISHED |
2016-01-11 |
|
| Date last modified |
2016-01-19 |
|
| definition |
A topical formulation containing the antimetabolite 5-fluorouracil (5-FU), with antineoplastic activity. Upon topical administration, 5-FU is converted into the active metabolite 5-fluoroxyuridine monophosphate (F-UMP), which competes with uracil during RNA synthesis and inhibits RNA processing. Conversion of 5-FU into another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase; this results in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in DNA synthesis, and thus inhibits DNA synthesis. Altogether, this prevents the proliferation of tumor cells locally. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C125194" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C125194" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C125194 |
|
| notation |
CDR0000777929 |
|
| NSC Code |
19893 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
topical fluorouracil |
|
| tui |
T109 T200 T114 T121 |