loading...| Preferred Name | hexaminolevulinate hydrochloride | |
| Synonyms |
Cysview Hexvix |
|
| Definitions |
The hydrochloride salt form of hexaminolevulinate, a hexyl ester of the heme precursor 5-aminolevulinic acid (ALA) with potential photosensitizing activity. Hexaminolevulinate serves as a precursor of photoactive porphyrins (PAPs), particularly protoporphyrin IX (PpIX), which selectively accumulate in rapidly proliferating cells, such as those seen in tumor tissue. When exposed to blue light, PAPs are activated and emit red light thereby allowing tumor imaging. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C73601" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C73601" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000776656 |
|
| altLabel |
Cysview Hexvix |
|
| CAS Registry |
140898-91-5 |
|
| cui |
C1327842 C1950837 C3817338 |
|
| DATE FIRST PUBLISHED |
2015-11-02 |
|
| Date last modified |
2015-10-30 |
|
| definition |
The hydrochloride salt form of hexaminolevulinate, a hexyl ester of the heme precursor 5-aminolevulinic acid (ALA) with potential photosensitizing activity. Hexaminolevulinate serves as a precursor of photoactive porphyrins (PAPs), particularly protoporphyrin IX (PpIX), which selectively accumulate in rapidly proliferating cells, such as those seen in tumor tissue. When exposed to blue light, PAPs are activated and emit red light thereby allowing tumor imaging. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C73601" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C73601" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C73601 |
|
| notation |
CDR0000776656 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
hexaminolevulinate hydrochloride |
|
| tui |
T109 T121 |