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Physician Data Query
Id | http://purl.bioontology.org/ontology/PDQ/CDR0000775374
http://purl.bioontology.org/ontology/PDQ/CDR0000775374
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Preferred Name | liraglutide |
Definitions |
A long-acting, fatty acylated glucagon-like peptide-1 (GLP-1) analog administered subcutaneously, with antihyperglycemic activity. Liraglutide's prolonged action and half-life of 11-15 hours are attributed to the attachment of the fatty acid palmitic acid to GLP-1 that reversibly binds to albumin. Albumin binding protects liraglutide from immediate degradation and elimination and causes GLP-1 to be released from abumin in a slow and consistent manner. This agent may cause thyroid C-cell tumors and increases the risk of acute pancreatitis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82239" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C82239" NCI Thesaurus)
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Synonyms |
N26-(hexadecanoyl-gamma-glutamyle)-(34-arginine)glucagon-like-peptide-1-(7-37)-peptide
Victoza
NN2211
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Type | http://www.w3.org/2002/07/owl#Class |
All Properties
definition | A long-acting, fatty acylated glucagon-like peptide-1 (GLP-1) analog administered subcutaneously, with antihyperglycemic activity. Liraglutide's prolonged action and half-life of 11-15 hours are attributed to the attachment of the fatty acid palmitic acid to GLP-1 that reversibly binds to albumin. Albumin binding protects liraglutide from immediate degradation and elimination and causes GLP-1 to be released from abumin in a slow and consistent manner. This agent may cause thyroid C-cell tumors and increases the risk of acute pancreatitis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82239" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C82239" NCI Thesaurus) |
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altLabel |
N26-(hexadecanoyl-gamma-glutamyle)-(34-arginine)glucagon-like-peptide-1-(7-37)-peptide
Victoza
NN2211
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prefLabel |
liraglutide
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CAS Registry |
204656-20-2
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notation |
CDR0000775374
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ORIG STY |
Drug/agent
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Date last modified |
2015-09-04
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Semantic type UMLS property | |
NCI ID |
C82239
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type | |
LT |
TRD
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tui |
T125
T116
T121
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DATE FIRST PUBLISHED |
2015-09-04
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cui |
C1456408
C1099192
C2732208
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