proflavine hemisulfate

acridine, 3,6-diamino-, sulfate (2:1)

The hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast and disinfectant agent that can potentially be used for cellular imaging and antiseptic purposes. Upon topical application of proflavine hemisulfate, proflavine diffuses into cells and intercalates into DNA, thereby accumulating in and staining the nucleus. During fluorescence imaging, the cell nuclei can be visualized. This allows nuclear morphometry and the identification of cancer cells. In addition, proflavine exerts its antibacterial effect by binding to bacterial DNA, thereby disrupting DNA synthesis and halting bacterial cell growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C84109" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C84109" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000771566

acridine, 3,6-diamino-, sulfate (2:1)

1811-28-5

2058-34-6

C0033295

2015-04-23

2015-06-11

The hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast and disinfectant agent that can potentially be used for cellular imaging and antiseptic purposes. Upon topical application of proflavine hemisulfate, proflavine diffuses into cells and intercalates into DNA, thereby accumulating in and staining the nucleus. During fluorescence imaging, the cell nuclei can be visualized. This allows nuclear morphometry and the identification of cancer cells. In addition, proflavine exerts its antibacterial effect by binding to bacterial DNA, thereby disrupting DNA synthesis and halting bacterial cell growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C84109" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C84109" NCI Thesaurus)

C84109

CDR0000771566

Drug/agent

proflavine hemisulfate

T109

T121