loading...| Preferred Name | levobupivacaine hydrochloride | |
| Synonyms |
Chirocaine |
|
| Definitions |
The hydrochloride salt of levobupivacaine, an amide derivative with anesthetic property. Levobupivacaine reversibly binds voltage-gated sodium channels to modulate ionic flux and prevent the initiation and transmission of nerve impulses (stabilizing neuronal membrane), thereby resulting in analgesia and anesthesia. In comparison with racemic bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61805" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61805" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000769079 |
|
| altLabel |
Chirocaine |
|
| CAS Registry |
27262-48-2 |
|
| cui |
C0875986 C0873119 |
|
| DATE FIRST PUBLISHED |
2015-02-11 |
|
| Date last modified |
2015-04-24 |
|
| definition |
The hydrochloride salt of levobupivacaine, an amide derivative with anesthetic property. Levobupivacaine reversibly binds voltage-gated sodium channels to modulate ionic flux and prevent the initiation and transmission of nerve impulses (stabilizing neuronal membrane), thereby resulting in analgesia and anesthesia. In comparison with racemic bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61805" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61805" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C61805 |
|
| notation |
CDR0000769079 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
levobupivacaine hydrochloride |
|
| tui |
T109 T121 |