ingenol mebutate gel

Picato

A topical, aqueous gel formulation containing the mebutate salt form of ingenol, a selective small-molecule activator of protein kinase C (PKC) that is isolated from the sap of Euphorbia species, with potential antineoplastic activity. Upon topical application of the ingenol mebutate gel, ingenol activates various PKC isoforms, which induces apoptosis in certain tumor cells, including myeloid leukemia cells, melanoma cells, and basal cell carcinoma cells. The PKC family consists of signaling isoenzymes that regulate many cell processes, including proliferation, differentiation, and apoptosis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C118776" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C118776" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000766480

Picato

PEP-005 topical gel

3-angel oyl ingenol gel

PEP005 gel

ingenol-3-angelate gel

C3896792

C3898761

C3257744

2014-11-13

2015-01-14

A topical, aqueous gel formulation containing the mebutate salt form of ingenol, a selective small-molecule activator of protein kinase C (PKC) that is isolated from the sap of Euphorbia species, with potential antineoplastic activity. Upon topical application of the ingenol mebutate gel, ingenol activates various PKC isoforms, which induces apoptosis in certain tumor cells, including myeloid leukemia cells, melanoma cells, and basal cell carcinoma cells. The PKC family consists of signaling isoenzymes that regulate many cell processes, including proliferation, differentiation, and apoptosis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C118776" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C118776" NCI Thesaurus)

TRD

C118776

CDR0000766480

Drug/agent

ingenol mebutate gel

T109

T121