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| Preferred Name | dabigatran etexilate mesylate | |
| Synonyms |
BIBR 1048 MS Pradaxa BIBR 1048MS beta-alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl] phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester, methanesulfonate |
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| Definitions |
An orally available mesylate salt form of the etexilate prodrug of dabigatran, a benzimidazole and direct thrombin inhibitor with anticoagulant activity. Upon administration, dabigatran etexilate is hydrolyzed by esterases and is converted into dabigatran. Dabigatran reversibly binds to and inhibits the activity of thrombin, a serine protease that converts fibrinogen into fibrin. This disrupts the coagulation cascade and inhibits the formation of blood clots. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C90702" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C90702" NCI Thesaurus) |
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| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000763237 |
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| altLabel |
BIBR 1048 MS Pradaxa BIBR 1048MS beta-alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl] phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester, methanesulfonate
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| CAS Registry |
872728-81-9
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|
| cui |
C4282225 C2987526 C2343849 C2940579
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| DATE FIRST PUBLISHED |
2014-07-23
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| Date last modified |
2014-08-13
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|
| definition |
An orally available mesylate salt form of the etexilate prodrug of dabigatran, a benzimidazole and direct thrombin inhibitor with anticoagulant activity. Upon administration, dabigatran etexilate is hydrolyzed by esterases and is converted into dabigatran. Dabigatran reversibly binds to and inhibits the activity of thrombin, a serine protease that converts fibrinogen into fibrin. This disrupts the coagulation cascade and inhibits the formation of blood clots. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C90702" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C90702" NCI Thesaurus)
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| LT |
TRD
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| NCI ID |
C90702
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| notation |
CDR0000763237
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| ORIG STY |
Drug/agent
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| prefLabel |
dabigatran etexilate mesylate
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| tui |
T109 T121
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