loading...| Preferred Name | calcipotriene | |
| Synonyms |
calcipotriol Dovonex |
|
| Definitions |
A synthetic vitamin D derivative usually formulated for topical dermatological use, antipsoriatic calcipotriene (calcipotriol) competes equally with active 1,25-hydroxy-2D3 (the natural form of vitamin D) for 1,25-hydroxy-2D3 receptors in regulating cell proliferation and differentiation. It induces differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and leads to normalization of epidermal growth. |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000752368 |
|
| altLabel |
calcipotriol Dovonex |
|
| CAS Registry |
112828-00-9 112965-21-6 |
|
| cui |
C0720029 C0065767 |
|
| DATE FIRST PUBLISHED |
2013-09-09 |
|
| Date last modified |
2013-09-09 |
|
| definition |
A synthetic vitamin D derivative usually formulated for topical dermatological use, antipsoriatic calcipotriene (calcipotriol) competes equally with active 1,25-hydroxy-2D3 (the natural form of vitamin D) for 1,25-hydroxy-2D3 receptors in regulating cell proliferation and differentiation. It induces differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and leads to normalization of epidermal growth. |
|
| LT |
TRD |
|
| notation |
CDR0000752368 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
calcipotriene |
|
| tui |
T109 T121 |