Preferred Name | ALK inhibitor RO5424802 | |
Synonyms |
RO5424802 |
|
Definitions |
An orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, ALK inhibitor RO5424802 binds to and inhibits ALK kinase, which leads to a disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors. Additionally, ALK mutations are associated with acquired resistance to small molecule tyrosine kinase inhibitors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C105615" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C105615" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000747398 |
|
altLabel |
RO5424802 |
|
cui |
C3642266 |
|
DATE FIRST PUBLISHED |
2013-03-07 |
|
Date last modified |
2013-03-21 |
|
definition |
An orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, ALK inhibitor RO5424802 binds to and inhibits ALK kinase, which leads to a disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors. Additionally, ALK mutations are associated with acquired resistance to small molecule tyrosine kinase inhibitors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C105615" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C105615" NCI Thesaurus) |
|
NCI ID |
C105615 |
|
notation |
CDR0000747398 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
ALK inhibitor RO5424802 |
|
tui |
T109 T121 |
Delete | Mapping To | Ontology | Source |
---|---|---|---|
http://purl.bioontology.org/ontology/MESH/C582670 | MESH | CUI |