loading...| Preferred Name | galantamine hydrobromide | |
| Synonyms |
lycoremine hydrobromide Reminyl Razadyne Nivalin |
|
| Definitions |
The hydrobromide salt form of galantamine, a tertiary alkaloid obtained synthetically or naturally from the bulbs and flowers of Narcissus and several other genera of the Amaryllidaceae family with anticholinesterase and neurocognitive-enhancing activities. Galantamine competitively and reversibly inhibits acetylcholinesterase, thereby increasing the concentration and enhancing the action of acetylcholine (Ach). In addition, galantamine is a ligand for nicotinic acetylcholine receptors, which may increase the presynaptic release of Ach and activate postsynaptic receptors. This agent may improve neurocognitive function in mild and moderate Alzheimer' s disease and may reduce abstinence-induced cognitive symptoms that promote smoking relapse. |
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| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000739214 |
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| altLabel |
lycoremine hydrobromide Reminyl Razadyne Nivalin |
|
| cui |
C0028221 C0939465 C0949312 |
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| DATE FIRST PUBLISHED |
2012-08-25 |
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| Date last modified |
2012-09-06 |
|
| definition |
The hydrobromide salt form of galantamine, a tertiary alkaloid obtained synthetically or naturally from the bulbs and flowers of Narcissus and several other genera of the Amaryllidaceae family with anticholinesterase and neurocognitive-enhancing activities. Galantamine competitively and reversibly inhibits acetylcholinesterase, thereby increasing the concentration and enhancing the action of acetylcholine (Ach). In addition, galantamine is a ligand for nicotinic acetylcholine receptors, which may increase the presynaptic release of Ach and activate postsynaptic receptors. This agent may improve neurocognitive function in mild and moderate Alzheimer' s disease and may reduce abstinence-induced cognitive symptoms that promote smoking relapse. |
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| LT |
TRD |
|
| notation |
CDR0000739214 |
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| ORIG STY |
Drug/agent |
|
| prefLabel |
galantamine hydrobromide |
|
| tui |
T109 T121 |