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Physician Data Query
| Preferred Name | belimumab | |
| Synonyms |
Benlysta LymphoStat-B antibody |
|
| Definitions |
A fully human IgG1 monoclonal antibody directed against B-Lymphocyte stimulator protein (BlyS or TNFSF13B) with potential immunomodulating activity. Belimumab specifically recognizes and inhibits the biological activity of BlyS, thereby preventing the binding of BlyS to B-lymphocytes. This inhibits the maturation of B-lymphocytes and may induce apoptosis in B-lymphocytes. In addition, it may decrease B-lymphocyte proliferation and/or survival. BlyS, a member of TNF family supporting B-lymphocyte maturation and survival, has been implicated in the pathogenesis of autoimmune diseases and B-lymphocyte malignancies. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C91385" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C91385" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000680522 |
|
| altLabel |
Benlysta LymphoStat-B antibody
|
|
| CAS Registry |
356547-88-1
|
|
| cui |
C2980433 C1723401 C4733190
|
|
| DATE FIRST PUBLISHED |
2010-06-21
|
|
| Date last modified |
2010-11-04
|
|
| definition |
A fully human IgG1 monoclonal antibody directed against B-Lymphocyte stimulator protein (BlyS or TNFSF13B) with potential immunomodulating activity. Belimumab specifically recognizes and inhibits the biological activity of BlyS, thereby preventing the binding of BlyS to B-lymphocytes. This inhibits the maturation of B-lymphocytes and may induce apoptosis in B-lymphocytes. In addition, it may decrease B-lymphocyte proliferation and/or survival. BlyS, a member of TNF family supporting B-lymphocyte maturation and survival, has been implicated in the pathogenesis of autoimmune diseases and B-lymphocyte malignancies. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C91385" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C91385" NCI Thesaurus)
|
|
| LT |
TRD
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|
| NCI ID |
C91385
|
|
| notation |
CDR0000680522
|
|
| ORIG STY |
Drug/agent
|
|
| prefLabel |
belimumab
|
|
| tui |
T116 T129 T121
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