Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

vardenafil hydrochloride

Synonyms

Levitra

Definitions

The hydrochloride salt form of vardenafil, a benzenesulfonamide derivative and phosphodiesterase type 5 (PDE5) inhibitor with vasodilatory activity. Vardenafil selectively inhibits PDE5, thus inhibiting the degradation of cyclic guanosine monophosphate (cGMP) found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. The inhibition of cGMP degradation results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, thereby prolonging penile erection. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C76318" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C76318" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000670474

altLabel

Levitra

CAS Registry

330808-88-3

cui

C0972333

C1174890

DATE FIRST PUBLISHED

2010-04-09

Date last modified

2010-10-04

definition

The hydrochloride salt form of vardenafil, a benzenesulfonamide derivative and phosphodiesterase type 5 (PDE5) inhibitor with vasodilatory activity. Vardenafil selectively inhibits PDE5, thus inhibiting the degradation of cyclic guanosine monophosphate (cGMP) found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. The inhibition of cGMP degradation results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, thereby prolonging penile erection. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C76318" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C76318" NCI Thesaurus)

LT

TRD

NCI ID

C76318

notation

CDR0000670474

ORIG STY

Drug/agent

prefLabel

vardenafil hydrochloride

tui

T109

T121

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