loading...| Preferred Name |
clioquinol |
|
| Synonyms |
5-chloro-7-iodo-quinolin-8-ol |
|
| Definitions |
An orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities. Clioquinol forms a stable chelate with copper (copper (II) ions), which inhibits the chymotrypsin-like activity of the proteasome; consequently, ubiquitinated proteins may accumulate in tumor cells, followed by tumor cell apoptosis and the inhibition of tumor angiogenesis. In addition, the clioquinol-copper complex appears to decrease the expression of androgen receptors (AR) in human copper-enriched prostate cancer cells. Serum levels of copper are often elevated in patients with cancer; copper chelation may inhibit copper-dependent endothelial cell proliferation and tumor secretion of angiogenic factors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C65337" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C65337" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000653982 |
|
| altLabel |
5-chloro-7-iodo-quinolin-8-ol |
|
| cui |
C0021978 |
|
| DATE FIRST PUBLISHED |
2009-08-31 |
|
| Date last modified |
2010-03-09 |
|
| definition |
An orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities. Clioquinol forms a stable chelate with copper (copper (II) ions), which inhibits the chymotrypsin-like activity of the proteasome; consequently, ubiquitinated proteins may accumulate in tumor cells, followed by tumor cell apoptosis and the inhibition of tumor angiogenesis. In addition, the clioquinol-copper complex appears to decrease the expression of androgen receptors (AR) in human copper-enriched prostate cancer cells. Serum levels of copper are often elevated in patients with cancer; copper chelation may inhibit copper-dependent endothelial cell proliferation and tumor secretion of angiogenic factors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C65337" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C65337" NCI Thesaurus) |
|
| NCI ID |
C65337 |
|
| notation |
CDR0000653982 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
clioquinol |
|
| tui |
T109 T121 |