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Physician Data Query
| Preferred Name | resveratrol formulation SRT501 | |
| Synonyms |
SRT501 |
|
| Definitions |
A proprietary formulation of resveratrol, a polyphenolic phytoalexin derived from grapes and other food products with potential antioxidant, anti-obesity, antidiabetic and chemopreventive activities. Resveratrol may activate sirtuin subtype 1 (SIRT-1). SIRT1 activation has been reported to inhibit tumorigenesis and tumor cell proliferation.SIRT-1 is a member of the silent information regulator 2 (SIR2) (or sirtuin) family of enzymes that plays an important role in mitochondrial activity and acts as a protein deacetylase. SIRT1 appears to be involved in the regulation of numerous transcription factors such as Nf-kB and p53. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C85484" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C85484" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000648245 |
|
| altLabel |
SRT501
|
|
| cui |
C2002402
|
|
| DATE FIRST PUBLISHED |
2009-06-25
|
|
| Date last modified |
2010-02-11
|
|
| definition |
A proprietary formulation of resveratrol, a polyphenolic phytoalexin derived from grapes and other food products with potential antioxidant, anti-obesity, antidiabetic and chemopreventive activities. Resveratrol may activate sirtuin subtype 1 (SIRT-1). SIRT1 activation has been reported to inhibit tumorigenesis and tumor cell proliferation.SIRT-1 is a member of the silent information regulator 2 (SIR2) (or sirtuin) family of enzymes that plays an important role in mitochondrial activity and acts as a protein deacetylase. SIRT1 appears to be involved in the regulation of numerous transcription factors such as Nf-kB and p53. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C85484" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C85484" NCI Thesaurus)
|
|
| NCI ID |
C85484
|
|
| notation |
CDR0000648245
|
|
| ORIG STY |
Drug/agent
|
|
| prefLabel |
resveratrol formulation SRT501
|
|
| tui |
T109 T121
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