loading...| Preferred Name | sodium dichloroacetate | |
| Synonyms |
DCA |
|
| Definitions |
The sodium salt of dichloroacetic acid with potential antineoplastic activity. Dichloroacetate ion inhibits pyruvate dehydrogenase kinase, resulting in the inhibition of glycolysis and a decrease in lactate production. This agent may stimulate apoptosis in cancer cells by restoring normal mitochondrial-induced apoptotic signaling. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C73591" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C73591" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000582893 |
|
| altLabel |
DCA |
|
| cui |
C0037501 |
|
| DATE FIRST PUBLISHED |
2007-12-19 |
|
| Date last modified |
2008-06-24 |
|
| definition |
The sodium salt of dichloroacetic acid with potential antineoplastic activity. Dichloroacetate ion inhibits pyruvate dehydrogenase kinase, resulting in the inhibition of glycolysis and a decrease in lactate production. This agent may stimulate apoptosis in cancer cells by restoring normal mitochondrial-induced apoptotic signaling. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C73591" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C73591" NCI Thesaurus) |
|
| NCI ID |
C73591 |
|
| notation |
CDR0000582893 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
sodium dichloroacetate |
|
| tui |
T109 T121 |