loading...| Preferred Name | mirtazapine | |
| Synonyms |
Remeron |
|
| Definitions |
A synthetic tetracyclic derivative of the piperazino-azepines with antidepressant activity. Although its mechanism of action is unknown, mirtazapine enhances central adrenergic and serotonergic transmission, possibly by acting as an antagonist at central presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors. This agent is a potent antagonist of 5-hydroxytryptamine type 2 (5-HT2), 5-HT3, and histamine 1 (H1) receptors, and a moderate anatgonist of peripheral alpha 1 adrenergic and muscarinic receptors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29265" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29265" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000559298 |
|
| altLabel |
Remeron |
|
| CAS Registry |
61337-67-5 |
|
| cui |
C0049506 C0525726 |
|
| DATE FIRST PUBLISHED |
2007-07-06 |
|
| Date last modified |
2008-03-11 |
|
| definition |
A synthetic tetracyclic derivative of the piperazino-azepines with antidepressant activity. Although its mechanism of action is unknown, mirtazapine enhances central adrenergic and serotonergic transmission, possibly by acting as an antagonist at central presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors. This agent is a potent antagonist of 5-hydroxytryptamine type 2 (5-HT2), 5-HT3, and histamine 1 (H1) receptors, and a moderate anatgonist of peripheral alpha 1 adrenergic and muscarinic receptors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29265" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29265" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C29265 |
|
| notation |
CDR0000559298 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
mirtazapine |
|
| tui |
T109 T121 |