loading...| Preferred Name | minocycline hydrochloride | |
| Synonyms |
Tri-minocycline Minocin Minomax 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride Dynacin Minomycin Vectrin |
|
| Definitions |
The hydrochloride salt of minocycline, a broad spectrum long-acting derivative of the antibiotic tetracycline, with antibacterial and anti-inflammatory activities. Minocycline binds to the bacterial 30S ribosomal subunit and interferes with the binding of tRNA to the ribosomal complex, thereby inhibiting protein translation in bacteria. In addition, minocycline inhibits the inflammatory enzyme 5-lipoxygenase (5LOX) and may impede T cell-microglia interactions; both activities may contribute to minocycline's neuroprotective effects. 5LOX catalyzes the synthesis of inflammatory mediators such as prostaglandins and leukotrienes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47622" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47622" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000552699 |
|
| altLabel |
Tri-minocycline Minocin Minomax 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride Dynacin Minomycin Vectrin |
|
| CAS Registry |
13614-98-7 |
|
| cui |
C0026186 C0724218 C3281328 C0720114 C0591806 C4721506 |
|
| DATE FIRST PUBLISHED |
2007-05-23 |
|
| Date last modified |
2007-10-22 |
|
| definition |
The hydrochloride salt of minocycline, a broad spectrum long-acting derivative of the antibiotic tetracycline, with antibacterial and anti-inflammatory activities. Minocycline binds to the bacterial 30S ribosomal subunit and interferes with the binding of tRNA to the ribosomal complex, thereby inhibiting protein translation in bacteria. In addition, minocycline inhibits the inflammatory enzyme 5-lipoxygenase (5LOX) and may impede T cell-microglia interactions; both activities may contribute to minocycline's neuroprotective effects. 5LOX catalyzes the synthesis of inflammatory mediators such as prostaglandins and leukotrienes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47622" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47622" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C47622 |
|
| notation |
CDR0000552699 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
minocycline hydrochloride |
|
| tui |
T109 T195 |