Physician Data Query

Last uploaded: August 28, 2024
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Preferred Name

therapeutic hemin
Synonyms

Panhematin
Definitions

A sterile, lyophilized powder of hemin, the Fe3+ oxidation product of heme (Fe2+), derived from processed red blood cells. Therapeutic hemin appears to inhibit delta-aminolevulinic acid (ALA) synthetase, a rate-limiting enzyme in the porphyrin/heme biosynthetic pathway, resulting in inhibition of the hepatic and/or marrow synthesis of porphyrin precursors. The mechanism by which therapeutic hematin produces symptomatic improvement in patients with acute episodes of the hepatic porphyrias has not been determined. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68925" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C68925" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000549706
altLabel

Panhematin
cui

C2348769

C0030316
DATE FIRST PUBLISHED

2007-05-11
Date last modified

2007-10-19
definition

A sterile, lyophilized powder of hemin, the Fe3+ oxidation product of heme (Fe2+), derived from processed red blood cells. Therapeutic hemin appears to inhibit delta-aminolevulinic acid (ALA) synthetase, a rate-limiting enzyme in the porphyrin/heme biosynthetic pathway, resulting in inhibition of the hepatic and/or marrow synthesis of porphyrin precursors. The mechanism by which therapeutic hematin produces symptomatic improvement in patients with acute episodes of the hepatic porphyrias has not been determined. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68925" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C68925" NCI Thesaurus)
LT

TRD
NCI ID

C68925
notation

CDR0000549706
ORIG STY

Drug/agent
prefLabel

therapeutic hemin
tui

T109

T121
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