loading...| Preferred Name | efavirenz | |
| Synonyms |
L743726 Sustiva DMP-266 Stocrin |
|
| Definitions |
A synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. Efavirenz binds directly to the human immunodeficiency virus type 1 (HIV-1) RT, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication. In combination with other antiretroviral drugs, this agent has been shown to significantly reduce HIV viral load, retarding or preventing damage to the immune system and reducing the risk of developing AIDS. Efavirenz induces activity of the cytochrome P450 system, accelerating its own metabolism. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29027" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29027" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000540650 |
|
| altLabel |
L743726 Sustiva DMP-266 Stocrin |
|
| cui |
C0387218 C0674427 C0674428 C0387216 C1095920 |
|
| DATE FIRST PUBLISHED |
2007-04-02 |
|
| Date last modified |
2008-03-11 |
|
| definition |
A synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. Efavirenz binds directly to the human immunodeficiency virus type 1 (HIV-1) RT, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication. In combination with other antiretroviral drugs, this agent has been shown to significantly reduce HIV viral load, retarding or preventing damage to the immune system and reducing the risk of developing AIDS. Efavirenz induces activity of the cytochrome P450 system, accelerating its own metabolism. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29027" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29027" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C29027 |
|
| notation |
CDR0000540650 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
efavirenz |
|
| tui |
T109 T121 |