loading...| Preferred Name |
acyclovir sodium |
|
| Synonyms |
Zovirax |
|
| Definitions |
The sodium salt form of acyclovir, a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses. After conversion in vivo to the active metabolite acyclovir triphosphate, acyclovir competitively inhibits viral DNA polymerase, incorporates into and terminates the growing viral DNA chain, and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared to VZV is due to its more efficient phosphorylation by the thymidine kinase of HSV. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47956" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47956" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000531923 |
|
| altLabel |
Zovirax |
|
| cui |
C0282040 C0592290 |
|
| DATE FIRST PUBLISHED |
2007-01-25 |
|
| definition |
The sodium salt form of acyclovir, a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses. After conversion in vivo to the active metabolite acyclovir triphosphate, acyclovir competitively inhibits viral DNA polymerase, incorporates into and terminates the growing viral DNA chain, and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared to VZV is due to its more efficient phosphorylation by the thymidine kinase of HSV. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47956" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47956" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C47956 |
|
| notation |
CDR0000531923 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
acyclovir sodium |
|
| tui |
T114 T121 |