Physician Data Query

Last uploaded: January 31, 2024
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Preferred Name

ampicillin sodium/sulbactam sodium
Synonyms

Unasyn
Definitions

A combination formulation of the sodium salts of the antibiotic ampicillin and the beta-lactamase inhibitor sulbactam with antibacterial activity. Ampicillin, a broad-spectrum, semisynthetic penicillin, binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. As a result, the cell wall is weakened and the cell lyses. The sulbactam component irreversibly binds to bacterial beta-lactamase at or near its active site, thereby interfering with substrate binding and inhibiting bacterial metabolism of penicillin and cephalosporin beta-lactam antibiotics, effectively extending their antibiotic spectrum to include many beta-lactam-resistant bacteria. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28823" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28823" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000500377
altLabel

Unasyn
cui

C1510875

C0147814
DATE FIRST PUBLISHED

2006-08-06
definition

A combination formulation of the sodium salts of the antibiotic ampicillin and the beta-lactamase inhibitor sulbactam with antibacterial activity. Ampicillin, a broad-spectrum, semisynthetic penicillin, binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. As a result, the cell wall is weakened and the cell lyses. The sulbactam component irreversibly binds to bacterial beta-lactamase at or near its active site, thereby interfering with substrate binding and inhibiting bacterial metabolism of penicillin and cephalosporin beta-lactam antibiotics, effectively extending their antibiotic spectrum to include many beta-lactam-resistant bacteria. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28823" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28823" NCI Thesaurus)
LT

TRD
NCI ID

C28823
notation

CDR0000500377
ORIG STY

Drug/agent
prefLabel

ampicillin sodium/sulbactam sodium
tui

T109

T195
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