loading...| Preferred Name | aprotinin bovine | |
| Synonyms |
Trasylol |
|
| Definitions |
A single chain polypeptide isolated from bovine lung with antifibrinolytic and anti-inflammatory activities. As a broad-spectrum serine protease inhibitor, aprotinin bovine competitively and reversibly inhibits the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activator, and tissue and leukocytic proteinases, resulting in attenuation of the systemic inflammatory response (SIR), fibrinolysis, and thrombin generation. This agent also inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47402" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47402" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000480388 |
|
| altLabel |
Trasylol |
|
| cui |
C0592198 C0003641 |
|
| DATE FIRST PUBLISHED |
2006-04-14 |
|
| definition |
A single chain polypeptide isolated from bovine lung with antifibrinolytic and anti-inflammatory activities. As a broad-spectrum serine protease inhibitor, aprotinin bovine competitively and reversibly inhibits the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activator, and tissue and leukocytic proteinases, resulting in attenuation of the systemic inflammatory response (SIR), fibrinolysis, and thrombin generation. This agent also inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47402" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47402" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C47402 |
|
| notation |
CDR0000480388 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
aprotinin bovine |
|
| tui |
T116 T123 T121 |