loading...| Preferred Name | palbociclib | |
| Synonyms |
Ibrance PD-0332991 PD-332991 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one |
|
| Definitions |
An orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C49176" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C49176" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000454586 |
|
| altLabel |
Ibrance PD-0332991 PD-332991 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one |
|
| CAS Registry |
571190-30-2 |
|
| cui |
C3853822 C1568660 C3883373 |
|
| DATE FIRST PUBLISHED |
2005-11-04 |
|
| Date last modified |
2015-03-20 |
|
| definition |
An orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C49176" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C49176" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C49176 |
|
| notation |
CDR0000454586 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
palbociclib |
|
| tui |
T109 T121 |