loading...| Preferred Name |
ketamine hydrochloride |
|
| Synonyms |
Ketalar |
|
| Definitions |
The hydrochloride salt of a synthetic derivative of cyclohexanone with analgesic and anesthetic activities. Although its mechanism of action is not well understood, ketamine appears to non-competitively block N-methyl-D-aspartate (NMDA) receptors and may interact with opiod mu receptors and sigma receptors, thereby reducing pain perception, inducing sedation, and producing dissociative anesthesia. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29142" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29142" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000452041 |
|
| altLabel |
Ketalar |
|
| cui |
C0022613 C0700541 |
|
| DATE FIRST PUBLISHED |
2005-10-14 |
|
| Date last modified |
2008-03-03 |
|
| definition |
The hydrochloride salt of a synthetic derivative of cyclohexanone with analgesic and anesthetic activities. Although its mechanism of action is not well understood, ketamine appears to non-competitively block N-methyl-D-aspartate (NMDA) receptors and may interact with opiod mu receptors and sigma receptors, thereby reducing pain perception, inducing sedation, and producing dissociative anesthesia. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29142" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29142" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C29142 |
|
| notation |
CDR0000452041 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
ketamine hydrochloride |
|
| tui |
T109 T121 |