Physician Data Query

Last uploaded: August 27, 2019
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Preferred Name

ibandronate sodium
Synonyms

Bondronate

Boniva

ibandronate
Definitions

The sodium salt of ibadronic acid, a synthetic nitrogen-containing bisphosphonate. Ibandronic acid inhibits farnesyl pyrophosphate synthase, resulting in a reduction in geranylgeranyl GTPase signaling proteins and apoptosis of osteoclasts. This agent increases bone mineral density, decreases bone remodeling, inhibits osteoclast-mediated bone resorption, and reduces metastases-related and corticosteroid-related bone pain. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1670" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1670" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000365963
altLabel

Bondronate

Boniva

ibandronate
CAS Registry

138926-19-9
cui

C0772244

C1541222

C0918019

C0379199
DATE FIRST PUBLISHED

2004-04-23
Date last modified

2017-12-13
definition

The sodium salt of ibadronic acid, a synthetic nitrogen-containing bisphosphonate. Ibandronic acid inhibits farnesyl pyrophosphate synthase, resulting in a reduction in geranylgeranyl GTPase signaling proteins and apoptosis of osteoclasts. This agent increases bone mineral density, decreases bone remodeling, inhibits osteoclast-mediated bone resorption, and reduces metastases-related and corticosteroid-related bone pain. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1670" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1670" NCI Thesaurus)
LT

TRD
NCI ID

C1670
notation

CDR0000365963
ORIG STY

Drug/agent
prefLabel

ibandronate sodium
tui

T109

T121
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