loading...| Preferred Name | zileuton | |
| Synonyms |
Zyflo N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea (+-)-N-Hydroxy-N-(1-benzo[b]thien-2-ylethyl)-urea ZLT |
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| Definitions |
A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C26667" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C26667" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000285649 |
|
| altLabel |
Zyflo N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea (+-)-N-Hydroxy-N-(1-benzo[b]thien-2-ylethyl)-urea ZLT |
|
| CAS Registry |
111406-87-2 |
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| Component of | ||
| cui |
C0081408 C0724508 |
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| DATE FIRST PUBLISHED |
2003-02-21 |
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| Date last modified |
2006-09-28 |
|
| definition |
A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C26667" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C26667" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C26667 |
|
| notation |
CDR0000285649 |
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| ORIG STY |
Drug/agent |
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| prefLabel |
zileuton |
|
| tui |
T109 T121 |