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Last uploaded: August 28, 2024

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Preferred Name	thioguanine
Synonyms	6-thioguanine 2-aminopurine-6-thiol tioguanin Lanvis BW 5071 6 thioguanine 6-mercapto-2-aminopurine X 27 6-mercaptoguanine 2-aminopurin-6-thiol 6H-purine-6-thione, 2-amino-1,7-dihydro- (9CI) 2-amino 6MP Tabloid 2-amino-6-mercaptopurine TG Wellcome U3B 2-amino-1,7-dihydro-6H-purine-6-thione 2-amino-6-purinethiol 2-aminopurine-6(1H)-thione tioguanine 6 mercaptoguanine 6-TG WR-1141
Definitions	A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C876" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C876" NCI Thesaurus)
ID	http://purl.bioontology.org/ontology/PDQ/CDR0000043669
altLabel	6-thioguanine 2-aminopurine-6-thiol tioguanin Lanvis BW 5071 6 thioguanine 6-mercapto-2-aminopurine X 27 6-mercaptoguanine 2-aminopurin-6-thiol 6H-purine-6-thione, 2-amino-1,7-dihydro- (9CI) 2-amino 6MP Tabloid 2-amino-6-mercaptopurine TG Wellcome U3B 2-amino-1,7-dihydro-6H-purine-6-thione 2-amino-6-purinethiol 2-aminopurine-6(1H)-thione tioguanine 6 mercaptoguanine 6-TG WR-1141
CAS Registry	154-42-7
Component of	http://purl.bioontology.org/ontology/PDQ/CDR0000040878 http://purl.bioontology.org/ontology/PDQ/CDR0000043217 http://purl.bioontology.org/ontology/PDQ/CDR0000041092 http://purl.bioontology.org/ontology/PDQ/CDR0000041118 http://purl.bioontology.org/ontology/PDQ/CDR0000039042 http://purl.bioontology.org/ontology/PDQ/CDR0000039781 http://purl.bioontology.org/ontology/PDQ/CDR0000040156 http://purl.bioontology.org/ontology/PDQ/CDR0000039186 http://purl.bioontology.org/ontology/PDQ/CDR0000041314 http://purl.bioontology.org/ontology/PDQ/CDR0000038701 http://purl.bioontology.org/ontology/PDQ/CDR0000041350 http://purl.bioontology.org/ontology/PDQ/CDR0000040942 http://purl.bioontology.org/ontology/PDQ/CDR0000037927 http://purl.bioontology.org/ontology/PDQ/CDR0000039041 http://purl.bioontology.org/ontology/PDQ/CDR0000038700 http://purl.bioontology.org/ontology/PDQ/CDR0000039609 http://purl.bioontology.org/ontology/PDQ/CDR0000042398 http://purl.bioontology.org/ontology/PDQ/CDR0000041831 http://purl.bioontology.org/ontology/PDQ/CDR0000042411 http://purl.bioontology.org/ontology/PDQ/CDR0000038878 http://purl.bioontology.org/ontology/PDQ/CDR0000039312 http://purl.bioontology.org/ontology/PDQ/CDR0000042611 http://purl.bioontology.org/ontology/PDQ/CDR0000041812 http://purl.bioontology.org/ontology/PDQ/CDR0000039637 http://purl.bioontology.org/ontology/PDQ/CDR0000038879 http://purl.bioontology.org/ontology/PDQ/CDR0000039460 http://purl.bioontology.org/ontology/PDQ/CDR0000041111 http://purl.bioontology.org/ontology/PDQ/CDR0000043399 http://purl.bioontology.org/ontology/PDQ/CDR0000040974 http://purl.bioontology.org/ontology/PDQ/CDR0000040958 http://purl.bioontology.org/ontology/PDQ/CDR0000042173 http://purl.bioontology.org/ontology/PDQ/CDR0000041081 http://purl.bioontology.org/ontology/PDQ/CDR0000306480 http://purl.bioontology.org/ontology/PDQ/CDR0000039044 http://purl.bioontology.org/ontology/PDQ/CDR0000039692 http://purl.bioontology.org/ontology/PDQ/CDR0000043401 http://purl.bioontology.org/ontology/PDQ/CDR0000038733 http://purl.bioontology.org/ontology/PDQ/CDR0000042202 http://purl.bioontology.org/ontology/PDQ/CDR0000042172 http://purl.bioontology.org/ontology/PDQ/CDR0000041995 http://purl.bioontology.org/ontology/PDQ/CDR0000038285 http://purl.bioontology.org/ontology/PDQ/CDR0000039462 http://purl.bioontology.org/ontology/PDQ/CDR0000041311 http://purl.bioontology.org/ontology/PDQ/CDR0000038374 http://purl.bioontology.org/ontology/PDQ/CDR0000040412 http://purl.bioontology.org/ontology/PDQ/CDR0000043298 http://purl.bioontology.org/ontology/PDQ/CDR0000037925 http://purl.bioontology.org/ontology/PDQ/CDR0000042281 http://purl.bioontology.org/ontology/PDQ/CDR0000038840 http://purl.bioontology.org/ontology/PDQ/CDR0000043125 http://purl.bioontology.org/ontology/PDQ/CDR0000042424 http://purl.bioontology.org/ontology/PDQ/CDR0000043404 http://purl.bioontology.org/ontology/PDQ/CDR0000040877 http://purl.bioontology.org/ontology/PDQ/CDR0000039043 http://purl.bioontology.org/ontology/PDQ/CDR0000042412 http://purl.bioontology.org/ontology/PDQ/CDR0000042163 http://purl.bioontology.org/ontology/PDQ/CDR0000271916 http://purl.bioontology.org/ontology/PDQ/CDR0000042521 http://purl.bioontology.org/ontology/PDQ/CDR0000041315 http://purl.bioontology.org/ontology/PDQ/CDR0000038850 http://purl.bioontology.org/ontology/PDQ/CDR0000041353 http://purl.bioontology.org/ontology/PDQ/CDR0000040066 http://purl.bioontology.org/ontology/PDQ/CDR0000039101 http://purl.bioontology.org/ontology/PDQ/CDR0000041833 http://purl.bioontology.org/ontology/PDQ/CDR0000041035 http://purl.bioontology.org/ontology/PDQ/CDR0000042342 http://purl.bioontology.org/ontology/PDQ/CDR0000043132 http://purl.bioontology.org/ontology/PDQ/CDR0000042413 http://purl.bioontology.org/ontology/PDQ/CDR0000039386 http://purl.bioontology.org/ontology/PDQ/CDR0000039045 http://purl.bioontology.org/ontology/PDQ/CDR0000037832 http://purl.bioontology.org/ontology/PDQ/CDR0000043218 http://purl.bioontology.org/ontology/PDQ/CDR0000042175 http://purl.bioontology.org/ontology/PDQ/CDR0000040957 http://purl.bioontology.org/ontology/PDQ/CDR0000042174 http://purl.bioontology.org/ontology/PDQ/CDR0000041798 http://purl.bioontology.org/ontology/PDQ/CDR0000040873 http://purl.bioontology.org/ontology/PDQ/CDR0000039464 http://purl.bioontology.org/ontology/PDQ/CDR0000042097
cui	C0039902 C1521987 C1521983 C0591704 C1521984 C2350041 C1521986
Date last modified	2015-04-13
definition	A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C876" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C876" NCI Thesaurus)
IND Code	936 7258
Legacy PDQ ID	914
LT	TRD
NCI ID	C876
notation	CDR0000043669
NSC Code	752
ORIG STY	Drug/agent
prefLabel	thioguanine
tui	T109 T121

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/SNMI/C-78200	SNMI	CUI
http://purl.bioontology.org/ontology/RCD/x02gy	RCD	CUI
http://purl.bioontology.org/ontology/RXNORM/151956	RXNORM	CUI
http://purl.bioontology.org/ontology/LNC/MTHU014979	LOINC	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387407006	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/MSHFRE/D013866	MSHFRE	CUI
http://purl.bioontology.org/ontology/LNC/LP31792-2	LOINC	CUI
http://purl.bioontology.org/ontology/RXNORM/10485	RXNORM	CUI
http://purl.bioontology.org/ontology/LNC/MTHU027390	LOINC	CUI
http://purl.bioontology.org/ontology/VANDF/4018777	VANDF	CUI
http://purl.bioontology.org/ontology/ATC/L01BB03	ATC	CUI
http://purl.bioontology.org/ontology/MESH/D013866	MESH	CUI
http://purl.bioontology.org/ontology/SCTSPA/387407006	SCTSPA	CUI
http://purl.bioontology.org/ontology/LNC/LP30750-1	LOINC	CUI
http://purl.bioontology.org/ontology/RCD/h35..	RCD	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/72623000	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000007242	NDFRT	CUI
http://purl.bioontology.org/ontology/SCTSPA/72623000	SCTSPA	CUI
http://purl.bioontology.org/ontology/NDDF/002652	NDDF	CUI
http://purl.bioontology.org/ontology/CSP/2910-9038	CRISP	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147080	NDFRT	CUI
http://purl.bioontology.org/ontology/MESH/D013866	MESH	CUI
http://purl.bioontology.org/ontology/MESH/D013866	MESH	CUI
http://purl.bioontology.org/ontology/SNMI/C-78200	SNMI	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013866	RH-MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12188	OCHV	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU014979	LOINC	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387407006	SNOMEDCT	LOOM
http://www.co-ode.org/ontologies/galen#Thioguanine	GALEN	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C876	NCIT	LOOM
http://purl.bioontology.org/ontology/LNC/LP31792-2	LOINC	LOOM
http://purl.bioontology.org/ontology/RXNORM/10485	RXNORM	LOOM
http://purl.obolibrary.org/obo/CHEBI_9516	DDSS	LOOM
http://purl.bioontology.org/ontology/VANDF/4018777	VANDF	LOOM
http://purl.obolibrary.org/obo/OMIT_0014714	OMIT	LOOM
http://purl.bioontology.org/ontology/MESH/D013866	MESH	LOOM
http://purl.obolibrary.org/obo/MESH_D013866	BERO	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017871	PMAPP-PMO	LOOM
http://doe-generated-ontology.com/OntoAD#C0039902	ONTOAD	LOOM
http://purl.bioontology.org/ontology/RCD/h35..	RCD	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0039902	OCHV	LOOM
http://purl.bioontology.org/ontology/NDDF/002652	NDDF	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.759.854	RH-MESH	LOOM
http://purl.obolibrary.org/obo/NCIT_C876	BERO	LOOM
http://www.genomic-cds.org/ont/genomic-cds.owl#Thioguanine	GENE-CDS	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147080	NDFRT	LOOM
http://purl.jp/bio/4/id/200906070315424954	IOBC	LOOM