loading...| Preferred Name | Micafungin | |
| Synonyms |
FK463 |
|
| Definitions |
A semi-synthetic echinocandin derived from a natural product of the fungus Coleophama empedri with potent antifungal activity. Micafungin, like other cyclic lipopeptides, noncompetitively inhibits the fungal specific enzyme 1,3-beta-D-glucan synthase, an enzyme essential for fungal cell wall synthesis. Inhibition of this enzyme weakens of the cell wall, thereby leading to osmotic lysis and eventually, fungal cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1850" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1850" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000043552 |
|
| altLabel |
FK463 |
|
| cui |
C0879264 C1120386 |
|
| Date last modified |
2010-12-01 |
|
| definition |
A semi-synthetic echinocandin derived from a natural product of the fungus Coleophama empedri with potent antifungal activity. Micafungin, like other cyclic lipopeptides, noncompetitively inhibits the fungal specific enzyme 1,3-beta-D-glucan synthase, an enzyme essential for fungal cell wall synthesis. Inhibition of this enzyme weakens of the cell wall, thereby leading to osmotic lysis and eventually, fungal cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1850" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1850" NCI Thesaurus) |
|
| Legacy PDQ ID |
8810 |
|
| NCI ID |
C1850 |
|
| notation |
CDR0000043552 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
Micafungin |
|
| tui |
T195 T116 |